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Figure 3: (a) Microphotograph (20×) representing the histopathological slides of the right cortex from the intervention groups. H and E staining: Control - meningeal reaction, loss of molecular layer, mild loss of granular layer and moderate gliosis - confined to the molecular layer was seen; Sham - no abnormality; Aglepristone 10 mg/kg - mild gliosis and neuronal orientation were not much affected; BAX staining: Control - positive BAX staining; Sham - BAX downregulation; Aglepristone 10 mg/kg - BAX downregulation; Bcl-2 staining: Control - occasional positive bcl-2 staining; Sham - Bcl-2 negativity; Aglepristone 10 mg/kg - occasional positive Bcl-2 level; M30 Cytodeath staining: Control - M30 Cytodeath staining positive; Sham - M30 Cytodeath staining negative; Aglepristone 10 mg/kg - mild positivity of M30 Cytodeath staining seen; Abbreviation: BAX - Bcl-2-associated X protein; Bcl-2 - B-cell lymphoma 2; IHC - Immunohistochemistry; STP - N-salicyloyltryptamine. (b) Microphotograph (20×) representing the histopathological slides of the right cortex from the intervention groups. H and E staining: Aglepristone 20 mg/kg - no abnormality; STP 50 mg/kg - marked neuronal loss, axonal bulb formation, and diffuse axonal damage; STP 100 mg/kg - signs of recovery namely mild haphazard orientation of the neurons seen. BAX staining: Aglepristone 20 mg/kg - BAX staining positive; STP 50 mg/kg - BAX positive staining but less expression; STP 100 mg/kg - presence of BAX but down regulation were seen. Bcl-2 staining: Aglepristone 20 mg/kg - only one cell expressing Bcl-2 and downregulation of Bcl-2; STP 50 mg/kg - no change in expression of Bcl-2 in the cortex; STP 100 mg/kg - many positive cells expressing Bcl-2. M30 Cytodeath staining: Aglepristone 20 mg/kg - M30 Cytodeath staining positive; STP 50 mg/kg - M30 Cytodeath staining positive; STP 100 mg/kg - M30 Cytodeath staining negative. Abbreviation: BAX - Bcl-2-associated X protein; Bcl-2 - B-cell lymphoma 2; IHC - Immunohistochemistry; STP - N-salicyloyltryptamine

Figure 3: (a) Microphotograph (20×) representing the histopathological slides of the right cortex from the intervention groups. <b>H and E staining:</b> <i>Control - </i>meningeal reaction, loss of molecular layer, mild loss of granular layer and moderate gliosis - confined to the molecular layer was seen; <i>Sham - </i>no abnormality; <i>Aglepristone 10 mg/kg</i> - mild gliosis and neuronal orientation were not much affected; <b>BAX staining:</b> <i>Control</i> - positive BAX staining; <i>Sham</i> - BAX downregulation; <i>Aglepristone 10 mg/kg</i> - BAX downregulation; <b>Bcl-2 staining:</b> <i>Control</i> - occasional positive bcl-2 staining; <i>Sham</i> - Bcl-2 negativity;<i> Aglepristone 10 mg/kg</i> - occasional positive Bcl-2 level; <b>M30 Cytodeath staining:</b> <i>Control</i> - M30 Cytodeath staining positive; <i>Sham</i> - M30 Cytodeath staining negative; <i>Aglepristone 10 mg/kg</i> - mild positivity of M30 Cytodeath staining seen; Abbreviation: BAX - Bcl-2-associated X protein; Bcl-2 - B-cell lymphoma 2; IHC - Immunohistochemistry; STP - N-salicyloyltryptamine. (b) Microphotograph (20×) representing the histopathological slides of the right cortex from the intervention groups. <b>H and E staining:</b> <i>Aglepristone 20 mg/kg - </i>no abnormality; <i>STP 50 mg/kg - </i>marked neuronal loss, axonal bulb formation, and diffuse axonal damage; <i>STP 100 mg/kg</i> - signs of recovery namely mild haphazard orientation of the neurons seen. <b>BAX staining:</b> <i>Aglepristone 20 mg/kg</i> - BAX staining positive; <i>STP 50 mg/kg - </i>BAX positive staining but less expression; <i>STP 100 mg/kg</i> - presence of BAX but down regulation were seen. <b>Bcl-2 staining:</b> <i>Aglepristone 20 mg/kg</i> - only one cell expressing Bcl-2 and downregulation of Bcl-2; <i>STP 50 mg/kg</i> - no change in expression of Bcl-2 in the cortex; <i>STP 100 mg/kg</i> - many positive cells expressing Bcl-2. <b>M30 Cytodeath staining:</b> <i>Aglepristone 20 mg/kg</i> - M30 Cytodeath staining positive; <i>STP 50 mg/kg</i> - M30 Cytodeath staining positive; STP 100 mg/kg - M30 Cytodeath staining negative. Abbreviation: BAX - Bcl-2-associated X protein; Bcl-2 - B-cell lymphoma 2; IHC - Immunohistochemistry; STP - N-salicyloyltryptamine