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Figure 2: (a) Well-delineated tumor margin (H and E X100) (b) Multilayered rosette with an irregular shaped central lumen. Mitotic activity in cells lining the rosette (insert) (H and E × 400) (c) Ependymal true rosettes with a central lumen (H and E × 400). (d) Areas of tumor necrosis (H and E × 100) (e) High mitotic activity (H and E × 400) (f) Focal positive for GFAP (×400) (g and h) Perinuclear dot-like positivity for EMA and EBP-50 respectively (×400). (i) Focal positivity for desmin (×400). (j) High MIB-1 labeling index (×400). (k) Negative for p65RELA protein. (l) Electropherogram showing Type 1 C11orf95-RELA fusion

Figure 2: (a) Well-delineated tumor margin (H and E X100) (b) Multilayered rosette with an irregular shaped central lumen. Mitotic activity in cells lining the rosette (insert) (H and E × 400) (c) Ependymal true rosettes with a central lumen (H and E × 400). (d) Areas of tumor necrosis (H and E × 100) (e) High mitotic activity (H and E × 400) (f) Focal positive for GFAP (×400) (g and h) Perinuclear dot-like positivity for EMA and EBP-50 respectively (×400). (i) Focal positivity for desmin (×400). (j) High MIB-1 labeling index (×400). (k) Negative for p65RELA protein. (l) Electropherogram showing Type 1 C11orf95-RELA fusion