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Figure 2: Parkinsonism plus syndromes: (a) Multiple system atrophy (MSA): Axial brain MRI T2W sequence shows the “putaminal rim sign” (white arrow) in MSA-parkinsonism subtype; and, (b) the “hot-cross-bun sign” (black arrow) with middle cerebellar peduncle atrophy (black arrow head) in MSA-cerebellar subtype. (c) Progressive supranuclear palsy (PSP): Sagittal brain MRI T1W sequence shows the “hummingbird sign”, a sign of midbrain atrophy (white arrow head) without pontine atrophy. (d) Corticobasal syndrome (CBS): Axial brain MRI T1W sequence shows an asymmetrical frontoparietal atrophy which is greater in the left hemisphere

Figure 2: Parkinsonism plus syndromes: (a) <i>Multiple system atrophy (MSA)</i>: Axial brain MRI T2W sequence shows the “putaminal rim sign” (white arrow) in MSA-parkinsonism subtype; and, (b) the “hot-cross-bun sign” (black arrow) with middle cerebellar peduncle atrophy (black arrow head) in MSA-cerebellar subtype. (c) <i>Progressive supranuclear palsy (PSP)</i>: Sagittal brain MRI T1W sequence shows the “hummingbird sign”, a sign of midbrain atrophy (white arrow head) without pontine atrophy. (d) <i>Corticobasal syndrome (CBS)</i>: Axial brain MRI T1W sequence shows an asymmetrical frontoparietal atrophy which is greater in the left hemisphere