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2013| July-August | Volume 61 | Issue 4
Online since
September 4, 2013
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ORIGINAL ARTICLES
India's contribution on "Guillain-Barre syndrome": Mapping of 40 years research
Shri Ram
July-August 2013, 61(4):375-382
DOI
:10.4103/0028-3886.117612
PMID
:24005728
Objective:
Guillain-Barre Syndrome (GBS) is an acute inflammatory polyradiculoneuropathy causing limb weaknesses. The mortality is around 8%, with about 20% of patients remaining disabled. The purpose of this study is to examine the performance of Indian Medical Scientists in the area of GBS over a period of 40 years. India's contribution to GBS has been examined based on the global publication output and share, growth rate, citation impact, publication share in various field, highly cited papers and their impact, most productive authors and their citation impact and collaboration of research on GBS with the international community.
Materials and Methods:
The data for this study has been taken from Scopus, a multidisciplinary database using keywords GBS and Miller Fisher Syndrome. The contribution of India on GBS has been compared with different countries for its publication and citation count during a period of 40 years (1973-2012).
Results:
It is found that there were 10,633 publications available from global medical research covering the various aspects of GBS. India's share is 2.92% of global output and holds 10
th
rank in overall publication output on GBS, whereas United States topped the rank with the highest number of publications. Sanjay Gandhi Post-graduate Institute of Medical Research, Lucknow is the most productive institutions while Tally AB from the National Institute of Mental Health and Neurosciences, Bangalore is the most productive author who has contributed the highest number of papers on GBS.
Conclusion:
India is far behind in GBS research as compared to other countries like USA, as there might be a low case report of GBS in Indian population. Still the research focusing this disease is quite prominent and needs a careful medical attention through research capacity building in order to look for better treatment of the disease in Indian cases. This study shall be helpful in enhancing the awareness of the GBS by Indian scientists.
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2
Use of Indian smell identification test for evaluating olfaction in idiopathic Parkinson's disease patients in India
Jaiben George, Toney Jose, Madhuri Behari
July-August 2013, 61(4):365-370
DOI
:10.4103/0028-3886.117598
PMID
:24005726
Background:
Olfactory dysfunction in Parkinson's Disease (PD) has been recognized for a long time and a number of studies have been performed in various parts of the world, using culturally appropriate smell identification tests.
Objective:
In this study, for the first time, olfactory function has been assessed in the Indian Idiopathic Parkinson's Disease (IPD) patients using an indigenously developed smell test.
Materials and Methods:
Olfaction was assessed in 53 IPD patients and 50 healthy controls using SniffIn-sticks
®
test and Indian Smell Identification test (INSIT). In both these tests, the subjects were asked to identify the smell from a set of choices and were scored out of 10 and 12 for INSIT and SniffIn-sticks
®
test, respectively.
Results:
Both SniffIn-sticks
®
test and INSIT showed significant impairment in olfaction in IPD patients (
P
< 0.001). There was no significant correlation of the scores of both tests with Hoehn and Yahr (H and Y) stage, duration of illness and Levodopa Equivalent Daily Dose (LEDD). The tests had a high correlation,
r
= 0.75 (
P
< 0.001) and the area under the Receiver Operating Characteristic (ROC) curves did not differ significantly. Using a cut off value of 4 (values ≤ 4 indicating disease), INSIT showed a sensitivity of 79.2% and specificity of 78%.
Conclusion:
INSIT, being cheap, convenient and more acceptable in the Indian population, can be considered as a better alternative for SniffIn-sticks
®
test in the evaluation of olfaction in Indian PD subjects.
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14
In vitro
differentiation of cultured human CD34+ cells into astrocytes
Katari Venkatesh, Lokanathan Srikanth, Bhuma Vengamma, Chodimella Chandrasekhar, Akula Sanjeevkumar, Bodapati Chandra Mouleshwara Prasad, Potukuchi Venkata Gurunadha Krishna Sarma
July-August 2013, 61(4):383-388
DOI
:10.4103/0028-3886.117615
PMID
:24005729
Background:
Astrocytes are abundantly present as glial cells in the brain and play an important role in the regenerative processes. The possible role of stem cell derived astrocytes in the spinal cord injuries is possible related to their influence at the synaptic junctions.
Aim:
The present study is focused on in vitro differentiation of cultured human CD34+ cells into astrocytes.
Materials and Methods:
Granulocyte-colony stimulating factor mobilized human CD34+ cells were isolated from peripheral blood using apheresis method from a donor. These cells were further purified by fluorescence-activated cell sorting and cultured in Dulbecco's modified eagle's medium. Thus, cultured cells were induced with astrocyte defined medium (ADM) and in the differentiated astrocytes serine/threonine protein kinases (STPK) and glutamine synthetase (GLUL) activities were estimated. The expression of glial fibrillary acidic protein (GFAP) and GLUL were confirmed by reverse transcriptase-polymerase chain reaction (RT-PCR).
Results:
The cultured human CD34+ cells differentiated into astrocytes after 11 h of incubation in ADM. The RT-PCR experiment showed the expression of GLUL (1.5 kb) and GFAP (2.9 kb) in differentiated astrocytes. The high enzyme activities of GLUL and STPK in differentiated astrocytes compared with cultured human CD34+ cells confirmed astrocyte formation.
Conclusion:
In the present study, in vitro differentiation of stem cells with retinoic acid induction may result in the formation of astrocytes.
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17
EDITORIAL
Intracranial arachnoid cysts: Epileptic seizures
J.M.K. Murthy
July-August 2013, 61(4):343-344
DOI
:10.4103/0028-3886.117580
PMID
:24005721
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7
ORIGINAL ARTICLES
Endoscopic repair of CSF rhinorrhea: Necessity of fibrin glue
Satyawati Mohindra, Sandeep Mohindra, Karan Gupta
July-August 2013, 61(4):396-399
DOI
:10.4103/0028-3886.117619
PMID
:24005731
Objective:
The aim of this study is to compare the efficacy of cerebrospinal fluid (CSF) repair with and without fibrin glue in pediatric patients with CSF rhinorrhea treated endoscopically.
Materials and Methods:
This was a retrospective study carried out in the Departments of Otolaryngology and Neurosurgery at a tertiary care center between December 2005 and July 2010.
Results:
The 27 patients with CSF rhinorrhea included in the study were divided into Group A: 13 patients who underwent endoscopic endonasal CSF repair using fibrin glue (Tisseel, Baxter, Vienna, Austria) by an endoscopic rhinologist and Group B: 14 patients who underwent endonasal CSF repair without fibrin glue. There was no statistically significant difference in endoscopic CSF repairs with or without fibrin glue (
P
= 0.48) in all the variables studied. CSF repair without fibrin glue appeared more cost saving as compared to repair with glue.
Conclusion:
CSF repairs with and without fibrin glue are equally effective and CSF repair without fibrin is costs saving.
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6
GNE
myopathy in India
Atchayaram Nalini, Narayanappa Gayathri, Ischizo Nishino, Yukiko K Hayashi
July-August 2013, 61(4):371-374
DOI
:10.4103/0028-3886.117609
PMID
:24005727
Background:
GNE myopathy is a clinicopathologically distinct distal myopathy with autosomal-recessive inheritance. The GNE gene mutations are known to cause this form of distal myopathy
Materials and Methods:
Over the last 6 years, a total of 54 patients from 48 families were diagnosed to have GNE myopathy based on the clinical and histopathological findings. We have reported on 23 cases earlier and from this cohort 12 patients from 11 families underwent genetic testing for GNE mutation.
Results:
Nine patients belonging to eight families were confirmed as GNE myopathy by genetic analysis. There were six women and three men. Mean age of onset was 26.7 ± 5.47 years (20-36 years) and mean age at clinical examination was 32.3 ± 4.2 years (28-39 years). Mean duration of the illness was 5.7 ± 4.7 years (1-14 years). All had characteristic clinical features of progressive weakness and wasting of the anterior part of leg muscles, adductors of thighs and hamstrings with relative sparing of the quadriceps muscles. Biopsy from the tibialis anterior muscles revealed the presence of rimmed vacuoles. Mutation analysis of the GNE gene revealed that c. 2086G > A (p.Val696Met) change was common in our series like Thailand and six of eight families carried this mutation, heterozygously.
Conclusion:
These results show the presence of a common mutation in GNE gene in Southeast Asia.
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21
CASE REPORTS
Biotinidase deficiency in childhood
Viswanathan Venkataraman, Padma Balaji, Debasis Panigrahi, Rafat Jamal
July-August 2013, 61(4):411-413
DOI
:10.4103/0028-3886.117614
PMID
:24005734
This study reports the clinical, laboratory profile and outcome in seven patients with biotinidase deficiency. The serum biotinidase activity was assayed using spectrophotometric analysis. The age at presentation varied from day 1 of life to the 5
th
month. Seizures were the presenting complaint in six patients and clonic seizures were the predominant seizure type. Sparse hair was seen in four patients, while three did not have any cutaneous manifestation. None of the patients had acidosis or hyperammonemia. The clinical response to biotin was dramatic with seizure control in all patients. One patient had neurological deficit at follow-up, while none had optic atrophy or sensorineural hearing loss. Biotinidase deficiency, a potentially treatable condition, should be thought of in any child presenting with neurological symptoms, especially seizures, even in the absence of cutaneous or laboratory manifestations.
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7,902
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9
ORIGINAL ARTICLES
Quality of life and psychiatric co‑morbidity in Indian migraine patients: A headache clinic sample
Kartavya Sharma, Rahul Remanan, Sumit Singh
July-August 2013, 61(4):355-359
DOI
:10.4103/0028-3886.117584
PMID
:24005724
Background:
There is a lack of data from India on the impact of migraine on health-related quality of life (HRQoL) and the extent of psychiatric co-morbidities in migraine.
Objective:
The objectives of the study were to quantify the impairment in HRQoL in migraine patients compared to healthy controls, to compare the prevalence of clinically significant anxiety and depressive symptoms in these groups, and to identify patient and headache characteristics that may predict health-related quality of life.
Materials and Methods:
We interviewed 71 consecutive newly diagnosed migraine patients seen in the headache clinic of a tertiary referral center between September and December 2008. Age- and sex-matched healthy subjects (
n
= 71) were used as controls. Short Form-36, Migraine Disability Assessment Score, and Hospital Anxiety and Depression Scale were administered. Predictors of HRQoL were identified using regression analysis.
Results:
Migraineurs were significantly impaired in all subscales of the SF-36 compared to controls, with greatest impairments in role physical, general health, and role emotional subscales. Prevalence of clinically significant anxiety (48%) and depressive (41%) symptoms in patients was higher than in healthy controls. Female gender, headache-related disability, and severity of anxiety predicted worse Physical Component Summary scores, while severity of both anxiety and depressive symptoms predicted worse Mental Component Summary scores.
Conclusion:
HRQoL is significantly reduced in Indian migraine patients compared to healthy controls. Incidence of clinically significant anxiety and depressive symptoms is also much higher in these patients. These findings corroborate well with studies from other parts of the world and suggest that cultural differences do not significantly alter the subjective impact of migraine on quality of life.
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REVIEW ARTICLE
Deep brain stimulation: Lessons learned in 25 years and future ahead
Sanjay Pandey
July-August 2013, 61(4):345-348
DOI
:10.4103/0028-3886.117581
PMID
:24005722
Deep brain stimulation (DBS) is a major advancement in the field of functional neurosurgery in the last century. This treatment option is now utilized for many hyperkinetic and hypokinetic movement disorders and certain disorders in the field of psychiatry. The basis of treatment is a by-product of excellent advancement made in the field of basic neuroscience and technology. Due to the improvement in the field of neuroimaging, brain structures are now better localized leading to a better outcome. Newer sites of stimulations are being recognized, which may further improve the clinical outcome in patients. However, it is very important to stick to stringent inclusion and exclusion criteria while selecting patients for DBS to get the best results.
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2
LETTERS TO EDITOR
Eales' disease with neurological complications
Sidharth Shankar Anand, Gautam Das, Durga Prasad Chakraborty, Shankar Prasad Saha, Biman Bose
July-August 2013, 61(4):428-429
DOI
:10.4103/0028-3886.117593
PMID
:24005742
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7,140
72
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Myeloneuropathy in a case of Hashimoto's disease
AK Kayal, LJ Basumatary, S Dutta, N Mahanta, S Islam, A Mahanta
July-August 2013, 61(4):426-428
DOI
:10.4103/0028-3886.117591
PMID
:24005741
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7,023
98
2
ORIGINAL ARTICLES
Spinal dural arterio-venous fistula: Clinico-radiological profile and outcome following surgical occlusion in an Indian neurosurgical center
Sivashanmugam Dhandapani, Aditya Gupta, Jasmeet Singh, BS Sharma, AK Mahapatra, VS Mehta
July-August 2013, 61(4):406-410
DOI
:10.4103/0028-3886.117616
PMID
:24005733
Background:
Spinal dural arteriovenous fistula (SDAVF) is a common type of spinal vascular lesion. However, there has not been any published study on its clinico-radiological characteristics or surgical outcome from India.
Aim:
The aim of this study was to determine the clinico-radiological features of patients with SDAVF, outcomes following surgical ligation of the fistula and the various factors involved.
Materials and Methods:
Patients who were operated for SDAVF were studied for demographic details, symptoms, clinical severity, radiological features and neurological outcome in the form of improvement in gait disability grades. Appropriate statistical tests were performed.
Results:
There were 22 (19 males, 3 females) patients of SDAVF who underwent surgical ligation with a mean age of 55 years. The mean duration of symptoms at presentation was 15 months. Three patients had acute onset while the rest had insidious onset of symptoms. Out of the 22 patients, 11 (50%) had motor weakness as the first symptom, 13 (59%) were bedridden and 19 (86.4%) had bladder involvement at presentation. Thirteen patients had fistulae in thoracic spine, whereas eight had fistulae in the lumbar spine. All had a favorable outcome in the form of at least non-progression of gait disability (14 had improvement while 8 had stabilized). The improvement was non-significantly associated with younger age, acute onset, ambulant status and fistula below T9. It was inversely associated with pain as the first symptom and fluctuant clinical course.
Conclusion:
Surgical occlusion of SDAVF is usually associated with either improvement or stabilization of motor weakness.
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15
Susceptibility-weighted imaging: The value in cerebral astrocytomas grading
Hui Zhang, Yan Tan, Xiao-Chun Wang, Jiang-Bo Qing, Le Wang, Xiao-Feng Wu, Lei Zhang, Qi-wang Liu
July-August 2013, 61(4):389-395
DOI
:10.4103/0028-3886.117617
PMID
:24005730
Objective:
To investigate the value of susceptibility weighted imaging (SWI) in evaluating the histopathologic grade of cerebral astrocytomas and compare the relative value of SWI and conventional magnetic resonance imaging (MRI) sequences.
Materials and Methods:
This is an analysis of 26 untreated patients with pathologically confirmed astrocytomas. The tumors were classified as low grade (grade I-II: 12 cases) or high grade (grade III-IV: 14 cases). Imaging was performed with a 3.0 T MRI scanner. Conventional sequences [T1-weighted imaging (T1WI), contrast enhanced T1WI (CE-T1WI), T2-weighted imaging (T2WI), and T2 FLuid Attenuated Inversion Recovery (T2FLAIR)] and SWI sequence (including CE-SWI) were done. The number of small vessels and the amount of blood products in the tumors were determined for each sequence. Differences between the two groups were analyzed statistically.
Results:
SWI was more sensitive than conventional sequences (T1WI, CE-T1WI, T2WI, and T2FLAIR) in visualizing small vessels and microhemorrhages in cerebral astrocytomas (
P
< 0.01). CE-SWI was better than CE-T1WI sequences for visualizing tumor small vessels and microhemorrhages. SWI visualized greater numbers of small vessels and areas of microhemorrhages in high-grade tumors than in low-grade tumors (
P
< 0.01). This was especially true after contrast administration (
P
< 0.01).
Conclusion:
SWI plays an important role in astrocytoma grading, especially for enhanced astrocytomas after contrast injection. CE-SWI was better than CE-T1WI in visualizing tumor architecture.
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8
LETTERS TO EDITOR
Mesial temporal lobe epilepsy with hippocampal sclerosis preceded by eclampsia: A rare association
Dilip Singh, Arun Garg, Aditya Gupta, Atma Ram Bansal
July-August 2013, 61(4):421-422
DOI
:10.4103/0028-3886.117585
PMID
:24005737
[FULL TEXT]
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6,704
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CASE REPORTS
Severe form of radiculo - myelo - neuropathy with meningo - encephalitis secondary to Angiostrongylus cantonensis infection: Unusual corpus callosal lesions and serial magnetic resonance imaging findings
Atchayaram Nalini, Anil Ramakrishna, Paron Dekumoy, Raju Ravi Kumar, Wallop Pakdee, Jitender Saini, Vinay S Hegde
July-August 2013, 61(4):414-418
DOI
:10.4103/0028-3886.117613
PMID
:24005735
A 43-year-old man presented with the symptoms of recurrent lower abdominal pain, malaise and loss of appetite of 3-week duration, followed by acute onset of generalized paresthesias, fever and headache which progressed over few days to quadriparesis, altered sensorium, urinary and fecal incontinence. He had consumed raw tongue, liver, gall bladder and testicles of monitor lizard (Varanus bengalensis). Blood picture showed eosinophilia and cerebrospinal fluid (CSF) analysis revealed elevated protein and eosinophilia. Serum and CSF serology was positive for angiostrongyliasis. Magnetic resonance imaging showed focal hyperintense lesions in the corpus callosum and brainstem and an enhancing lesion in the cerebellum. Post-contrast T1-weighted axial images of spine showed evidence of cervical cord hyperintense lesions and root enhancement. Susceptibility weighted images/phase images showed unusual feature of multiple hemorrhagic lesions in the posterior fossa and supratentorial areas. Diffusion showed no restriction of corpus callosal lesions. Patient was treated with the high dose parenteral steroids with albendazole and at 6-month follow-up and had a remarkable recovery.
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6,553
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9
Compartment syndrome as a spectrum of purple glove syndrome following intravenous phenytoin administration in a young male: A case report and review of literature
Puneet Chhabra, Nikhil Gupta, Atul Kaushik
July-August 2013, 61(4):419-420
DOI
:10.4103/0028-3886.117611
PMID
:24005736
Compartment syndrome is a rare complication of spectrum of purple glove syndrome, seen as a side effect of intravenous phenytoin. This involves rapid discolouration of the involved limb along with edema and sometimes blistering of the skin also. Treatment is usually conservative and rarely requires surgery. We present a case of compartment syndrome following intravenous phenytoin administration and review of literature related to the case.
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4
ORIGINAL ARTICLES
Individual surgical treatment of intracranial arachnoid cyst in pediatric patients
Chao Wang, Guoqiang Han, Chao You, Chuangxi Liu, Jun Wang, Yunbiao Xiong
July-August 2013, 61(4):400-405
DOI
:10.4103/0028-3886.117618
PMID
:24005732
Background and Aim:
Intracranial arachnoid cysts (IAC) are benign congenital cystic lesions filled with cerebrospinal fluid (CSF). This study evaluated microsurgical craniotomy and endoscopy in the surgical treatment of IAC.
Materials and Methods:
Eight-one consecutive pediatric patients with IAC were surgically treated between January 2004 and January 2011. The surgical procedures included microsurgical craniotomy and endoscopy. Symptoms at presentation, location of IAC, surgical treatment options, and effectiveness were evaluated.
Results:
There were 43 males and 38 females and the mean age was 8.7 years (range between 1 month and 14 years) at the time of surgery. The cyst location was supratentorial in 72 patients and infratentorial in 9 patients, arachnoid cyst were identified. Follow-up period ranged between 2 and 8 years. Of the 49 patients with headache 83.67% of patients had cure and 10.2% had significant improvement. Of the eight patients with hydrocephalus and gait disturbances, six (75%) had complete total relief of symptoms and two (25%) patients had significant improvement. Four of the six patients with cognitive decline and weakness showed improvement. Of the 18 patients with epilepsy seizure freedom was: Engle class I grade I in 14 (77.78%) patients; class II in 2 (11.11%) patients; and class III in 2 (11.11%) patients. Follow-up studies from 2 to 8 years showed that headache was cured in 41 of the 49 cases (83.67%), significantly improved in 5 cases (10.20%), and showed no variation in 3 cases (6.12%). Hydrocephalus and gait disturbances were controlled in six of the eight cases (75.00%) and significantly improved in two cases (25.00%). Cognitive decline and weakness were obviously improved in four of the six cases (66.67%) and exhibited no variation in two cases (33.33%). According to the Engle standard, the following results were obtained from 18 patients with epilepsy: Grade I in 14 cases (77.78%); grade II in 2 cases (11.11%); and grade III in 2 cases (11.11%). Eleven cases with local or general enlarged skull exhibited no further progression. On follow-up computed tomography (CT) scan, there was variable alleviation of mass effect in all the 81 patients. Cystic size was significantly reduced in 65 patients with supratentorial arachnoid cysts and in 9 patients with infratentorial archnoid cysts. Twenty-one patients who had decreased skull thickness, had no further progression. Four patients who had cranioplasty had good outcome.
Conclusion:
The endoscopic approach was highly effective for most cases of IAC, particularly for cysts in the suprasellar and quadrigeminal regions as well as in the posterior fossa. Microsurgical craniotomy was recommended for IAC in the extracerebral convexity and intracerebrum. Local skull cranioplasty is needed for patients, or patients with preoperative diagnosis showed signs of cystic tumor and cyst-related epilepsy.
[ABSTRACT]
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5
LETTERS TO EDITOR
Embouchure dysfunction in a trumpet player
Mohit Sharma
July-August 2013, 61(4):422-423
DOI
:10.4103/0028-3886.117586
PMID
:24005738
[FULL TEXT]
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5,597
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ORIGINAL ARTICLES
Seasonal variation in the clinical recovery of patients with Guillain Barré syndrome requiring mechanical ventilation
Kamath Sriganesh, Archana Netto, Girish B Kulkarni, Arun B Taly, Ganne S Umamaheswara Rao
July-August 2013, 61(4):349-354
DOI
:10.4103/0028-3886.117582
PMID
:24005723
Background:
Guillain Barré Syndrome (GBS) has a variable clinical course. The influence of season on the rate of recovery has not been evaluated previously, despite documentation of seasonal variation in the occurrence of GBS. This study evaluated the influence of season on the rate of recovery from GBS.
Materials and Methods:
Records of 184 patients with GBS over a 10-year period were reviewed. Patients were divided into four groups depending on the date of admission: Q1 (March-May), Q2 (June-August), Q3 (September-November), and Q4 (December-February). Demographic characteristics and recovery characteristics (duration of mechanical ventilation, ICU and hospital stay, and time for recovery from the time of initiation of definitive therapy) were compared across the four quarters.
Results:
There was no significant difference in age, antecedent illnesses, treatment received, electrophysiological findings, and muscle power at admission across the four groups. Significant differences among various seasons were found with respect to duration of mechanical ventilation (23 ± 20, 36 ± 34, 27 ± 22, and 38 ± 28 days for Q1-Q4, respectively;
P
= 0.05), ICU stay (27 ± 22, 40 ± 37, 31 ± 23, and 43 ± 30 days for Q1-Q4, respectively;
P
= 0.05), hospital stay (42 ± 28, 55 ± 44, 47 ± 34, and 72 ± 54 days for Q1-Q4, respectively;
P
= 0.02), and time for recovery from treatment (15 ± 14, 29 ± 34, 18 ± 14, and 29 ± 20 days for Q1-Q4, respectively;
P
= 0.02).
Conclusions:
This study demonstrates a seasonal variation in the recovery of patients with GBS requiring mechanical ventilation. Patients admitted in Q1 have the fastest recovery and those in Q4 have the slowest recovery.
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4
Association of polymorphism in rs2736990 of the α-synuclein gene with Parkinson's disease in a Chinese population
Fenghua Pan, Haixia Ding, Hairong Dong, Min Ye, Weiguo Liu, Guiyun Cui, Jiechun Chen, Yanfeng Wu, Hui Wang, Xingzhen Dai, Haicun Shi, Xinsheng Ding
July-August 2013, 61(4):360-364
DOI
:10.4103/0028-3886.117595
PMID
:24005725
Background and Objective:
Previous genetic studies in Parkinson's disease (PD) have provided conclusive evidence for association of genes with strong biological rationale for PD. Recently several studies in different populations have found a strong association between idiopathic PD and the single-nucleotide polymorphism (SNP) rs2736990, located within an intron of the α-synuclein (SNCA) gene. In this study, we aimed to verify these findings and to explore the characteristic of the association in a subset of Chinese Han PD patients.
Materials and Methods:
A total of 515 unrelated patients with sporadic PD and 450 healthy ethnically matched control subjects were recruited consecutively for the study. Patients and healthy controls were genotyped for SNCA rs2736990 variant by polymerase chain reaction - ligase detection reaction.
Results:
Our data showed a significant association between the rs2736990 polymorphism and PD, the frequency of the allele C in PD patients was significantly higher than that in controls (
P
= 0.017, OR = 1.26, 95% confident intervals (CI) =1.04-1.51). The distribution of C > T genotypes was different between patients and controls (
P
= 0.027). Furthermore, allele C of SNP rs2736990 in early-onset PD was significantly more frequent than that in healthy controls (
P
= 0.007, odds ratio = 1.60, 95% CI = 1.13-2.26).
Conclusions:
Our study demonstrated that SNCA rs2736990 C > T polymorphism was associated with susceptibility to PD in Chinese Han population. Further studies are needed to replicate the association we found.
[ABSTRACT]
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[PubMed]
5,346
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8
LETTERS TO EDITOR
A rare case of non-traumatic intradiploic arachnoid cyst
Kanwaljeet Garg, Sumit Sinha, Shashank Sarad Kale, Rajinder Kumar, Bhawani Shankar Sharma
July-August 2013, 61(4):446-447
DOI
:10.4103/0028-3886.117605
PMID
:24005752
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4,772
61
3
Incidental giant frontal sinus mucocele with intracranial extension
Rakshith Srinivasa, Ravi Dadlani, Alangar S Hegde
July-August 2013, 61(4):447-448
DOI
:10.4103/0028-3886.117606
PMID
:24005753
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4,476
47
2
Antithymocyte globulin induced posterior reversible encephalopathy in aplastic anemia
Aniruddha Dayama, Tulika Seth, Pravas Mishra, Manoranjan Mahapatra
July-August 2013, 61(4):430-431
DOI
:10.4103/0028-3886.117594
PMID
:24005743
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4,453
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2
Acute ischemic stroke caused by paradoxical air embolism following injection sclerotherapy for varicose veins
Sweta Adatia, Vivek Nambiar, Ronak Kapadia, Ahmad Abuzinath, Sabrina Apel, Mustafa Alqarni, Suresh Subramaniam, Bijoy Menon
July-August 2013, 61(4):431-433
DOI
:10.4103/0028-3886.117596
PMID
:24005744
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4,240
50
5
Decompressive craniectomy in term pregnancy with combined cesarean section for traumatic brain injury
Pankaj Dawar, Aradhana Kalra, Deepak Agrawal, Bhawani S Sharma
July-August 2013, 61(4):423-425
DOI
:10.4103/0028-3886.117588
PMID
:24005739
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4,149
53
5
Ventriculo-ureteric shunt surgery: Thou shalt not be forgotten of me!
Hrishikesh Sarkar, A Karthikeyan
July-August 2013, 61(4):448-450
DOI
:10.4103/0028-3886.117607
PMID
:24005754
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4,069
50
6
Reconstructive endovascular treatment of fusiform basilar aneurysm with SILK flow diverter
Anand Alurkar, Lakshmi Sudha Prasanna Karanam, Sandeep Modh, Sandeep Sorte
July-August 2013, 61(4):425-426
DOI
:10.4103/0028-3886.117589
PMID
:24005740
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4,016
49
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Ventral herniation of the dorsal spinal cord: A rare cause of myelopathy
Prasad Krishnan, Rajaraman Kartikueyan, Debashish Chowdhury, Manash Saha
July-August 2013, 61(4):453-454
DOI
:10.4103/0028-3886.117610
PMID
:24005756
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3,889
77
1
Primary B-cell central nervous system lymphoma involving fourth ventricle: A rare case report with review of literature
Ram Nawal Rao, Deepti Mishra, Preeti Agrawal, Raj Kumar
July-August 2013, 61(4):450-453
DOI
:10.4103/0028-3886.117608
PMID
:24005755
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3,875
61
6
Mixed astroblastoma-arteriovenous malformation complex: A case report
Kun Yao, Tian-Fu Li, Ming-Wang Zhu, Ze-Jun Duan, Chang-Qing Liu, Ji-Qiang Wang, Ze-Liang Hu, Yu Bian, Xue-Ling Qi
July-August 2013, 61(4):439-442
DOI
:10.4103/0028-3886.117602
PMID
:24005749
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3,686
33
1
A rare intramedullary spinal cord metastasis from prostate carcinoma
Liemei Guo, Chunlong Zhong, Jiyao Jiang, Yongming Qiu
July-August 2013, 61(4):444-446
DOI
:10.4103/0028-3886.117604
PMID
:24005751
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3,657
42
2
Spontaneous spinal epidural hematoma during pregnancy: Case report and literature review
Zhi-Li Wang, Harrison X Bai, Li Yang
July-August 2013, 61(4):436-437
DOI
:10.4103/0028-3886.117600
PMID
:24005747
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3,618
52
3
Kissing aneurysm in a fenestrated mid-basilar arterial trunk: A case report and review of literature
Anita Jagetia, Manojkumar Bhutte, Rajendra Aher, Sanjeev Sinha, Daljeet Singh
July-August 2013, 61(4):437-439
DOI
:10.4103/0028-3886.117601
PMID
:24005748
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3,498
69
2
Cystic craniopharyngioma of lateral ventricle with small stalk in suprasellar cistern: A rare case
Sudhansu Sekhar Mishra, Sanjay K Behera, Satya Bhusan Senapati, Souvagya Panigrahi
July-August 2013, 61(4):434-436
DOI
:10.4103/0028-3886.117599
PMID
:24005746
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3,369
48
1
Intracranial germ cell tumor mimicking granulomatous inflammation
Sumit Thakar, Sunil V Furtado, Nandita Ghosal, Alangar S Hegde
July-August 2013, 61(4):433-434
DOI
:10.4103/0028-3886.117597
PMID
:24005745
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3,196
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Cavernous sinus but not intrasellar cavernous hemangioma
Bao-Yuan Zhou, Bo-Wen Cai, Yan-Hui Liu, Ying-Jun Fan
July-August 2013, 61(4):442-443
DOI
:10.4103/0028-3886.117603
PMID
:24005750
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3,147
39
2
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