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META-ANALYSIS
Year : 2022  |  Volume : 70  |  Issue : 4  |  Page : 1454--1459

Short-Term Efficacy Outcomes of Tenecteplase versus Alteplase for Acute Ischemic Stroke: A Meta-Analysis of 5 Randomized Trials

Leticia E Requiao1, Roberto S Oliveira1, Lorena S Reis1, Ana P B Assis1, Beatriz N G Moreno1, Luisa R Cordeiro1, Davi F Solla2 
1 Bahiana School of Medicine and Public Health, Salvador, Bahia, Brazil
2 Division of Neurosurgery, University of São Paulo, São Paulo, São Paulo, Brazil

Correspondence Address:
Leticia E Requiao
Bahiana School of Medicine and Public Health, Av. Dom João VI, 275, Brotas, Salvador, Bahia, 40290-000
Brazil

Tenecteplase (TNK) has been shown to be noninferior to Alteplase (ALT) for long term efficacy and safety outcomes. Whether this also applies to short term efficacy outcomes such as early clinical improvement and recanalization is unknown. To compare TNK and ALT regarding the short term efficacy outcomes: early neurological improvement and recanalization. The PRISMA was used to conduct a meta analysis, adapted to noninferiority analysis. The primary outcome was early (24–72 h) neurological improvement, defined as either NIHSS score 0 or reduction of at least 8 points compared to baseline. Recanalization was a secondary outcome. The noninferiority margin was set at 6.5%. Search strategy yielded 5 randomized clinical trials (1585 patients: 828 TNK, 757 ALT). Mean age was 70.8, 58.8% were men, mean baseline NIHSS was 7, and mean onset to treatment time was 148 min. Patients in intervention group received TNK at doses of 0.1 mg/kg (6.8%), 0.25 mg/kg (24.6%), and 0.4 mg/kg (68.6%), while all ALT patients received 0.9 mg/kg. In random effects meta analysis, TNK was noninferior to ALT for the primary outcome, early major neurological improvement (risk difference 8% in favor of TNK, 95% CI 1%–15%). Recanalization was also noninferior for the TNK compared to the ALT group (risk difference 9% in favor of TNK, 95% CI 6% to 23%). Fixed effects models yielded similarly noninferior results and signaled for a possible TNK superiority for both early neurological improvement and recanalization. TNK is noninferior to ALT at the short term efficacy outcomes: early neurological improvement and recanalization.


How to cite this article:
Requiao LE, Oliveira RS, Reis LS, B Assis AP, G Moreno BN, Cordeiro LR, Solla DF. Short-Term Efficacy Outcomes of Tenecteplase versus Alteplase for Acute Ischemic Stroke: A Meta-Analysis of 5 Randomized Trials.Neurol India 2022;70:1454-1459


How to cite this URL:
Requiao LE, Oliveira RS, Reis LS, B Assis AP, G Moreno BN, Cordeiro LR, Solla DF. Short-Term Efficacy Outcomes of Tenecteplase versus Alteplase for Acute Ischemic Stroke: A Meta-Analysis of 5 Randomized Trials. Neurol India [serial online] 2022 [cited 2022 Dec 2 ];70:1454-1459
Available from: https://www.neurologyindia.com/article.asp?issn=0028-3886;year=2022;volume=70;issue=4;spage=1454;epage=1459;aulast=Requiao;type=0