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CASE REPORT
Year : 2021  |  Volume : 69  |  Issue : 5  |  Page : 1424--1426

Catastrophic Presentation of COVID-19 with Solitary Large Denovo Tumefactive Demyelination

Samhita Panda1, Pratik Patel1, Saksham Jain1, Sanjiv Sharma1, Monalisa Vegda1, Apoorv Patel1, Sarbesh Tiwari2, Puneeth Babu Anne3, Navratan Suthar4, Bharat Kumar5, Vijaya Lakshmi Nag6 
1 Department of Neurology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
2 Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
3 Department of Transfusion Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
4 Department of Psychiatry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
5 Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
6 Department of Microbiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India

Correspondence Address:
Samhita Panda
Additional Professor and Head, Department of Neurology, All India Institute of Medical Sciences, Jodhpur, Rajasthan
India

Background: The ongoing Coronavirus disease-19 (COVID-19) pandemic has revealed a plethora of extrapulmonary manifestations including neurological presentations. To date, nervous system demyelination has been relatively infrequently reported in this setting. Also, while most data point toward immune activation as a causative process, few studies propound a direct effect. Case Description: A 35-year-old man presented with severe new-onset headache, hemiparesis, and focal seizures culminating in deeply altered sensorium. Radiological evaluation showed a large expansile demyelinating lesion in the right cerebral hemisphere. Nasopharyngeal swab COVID reverse transcription–polymerase chain reaction (RT-PCR) was positive. After initial non-response to steroids, the patient responded well to plasma exchange leading to complete recovery. Conclusions: This report highlights a case of active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection presenting with tumefactive demyelination and subsequent response to therapy. It is important to recognize atypical presentations at this juncture as it may be crucial for planning treatment strategies.


How to cite this article:
Panda S, Patel P, Jain S, Sharma S, Vegda M, Patel A, Tiwari S, Anne PB, Suthar N, Kumar B, Nag VL. Catastrophic Presentation of COVID-19 with Solitary Large Denovo Tumefactive Demyelination.Neurol India 2021;69:1424-1426


How to cite this URL:
Panda S, Patel P, Jain S, Sharma S, Vegda M, Patel A, Tiwari S, Anne PB, Suthar N, Kumar B, Nag VL. Catastrophic Presentation of COVID-19 with Solitary Large Denovo Tumefactive Demyelination. Neurol India [serial online] 2021 [cited 2022 Jan 27 ];69:1424-1426
Available from: https://www.neurologyindia.com/article.asp?issn=0028-3886;year=2021;volume=69;issue=5;spage=1424;epage=1426;aulast=Panda;type=0