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Year : 2020  |  Volume : 68  |  Issue : 6  |  Page : 1509--1510

Linear Trigeminal Pontine Lesion in Multiple Sclerosis-related Trigeminal Neuropathy

Hung Youl Seok1, Mi-Yeon Eun2,  
1 Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Republic of Korea
2 Department of Neurology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea

Correspondence Address:
Dr. Mi-Yeon Eun
Department of Neurology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, 807 Hoguk-ro, Buk-gu, Daegu 41404
Republic of Korea

How to cite this article:
Seok HY, Eun MY. Linear Trigeminal Pontine Lesion in Multiple Sclerosis-related Trigeminal Neuropathy.Neurol India 2020;68:1509-1510

How to cite this URL:
Seok HY, Eun MY. Linear Trigeminal Pontine Lesion in Multiple Sclerosis-related Trigeminal Neuropathy. Neurol India [serial online] 2020 [cited 2021 Mar 3 ];68:1509-1510
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Full Text

A 31-year-old man presented with ten days of numbness in his left tongue and lips as if he just had dental anesthesia. The numbness subsequently extended to the left cheek and chin. There were no associated pain, weakness, or any other neurological symptoms. Nine months previously, he had been admitted for short transverse myelitis at the C2 level, which was his first clinical event [Figure 1]. On examination, facial sensation was intact to pinprick, light touch, and vibration. Brain magnetic resonance imaging (MRI) revealed a linear hyperintense lesion in the left pontine trigeminal root entry zone (REZ) with gadolinium enhancement [Figure 2]. Immunologic serum markers including anti-aquaporin-4 antibody and cerebrospinal fluid analysis were normal. We diagnosed him with clinically definite relapsing-remitting multiple sclerosis (MS) based on the McDonald criteria.[1] He was treated with five days of intravenous methylprednisolone (1g/day) and was then started subcutaneous interferon beta-1b to prevent further attacks. Two weeks later, his symptoms were almost improved. In MS, the trigeminal REZ lesion can appear to be either symptomatic or asymptomatic.[2],[3] In symptomatic cases, clinical phenotypes are diverse, ranging from trigeminal neuralgia, which is characterized by facial pain, to trigeminal neuropathy, which is characterized by facial numbness.[4],[5] Pontine trigeminal REZ lesion can also be seen in pontine infarction.[6] Distinguishing MS from pontine infarction in patients with trigeminal REZ lesion is difficult by imaging features alone and must be considered together with clinical findings. MS usually has a trigeminal REZ lesion with a linear appearance and no other ischemic lesions on MRI.[7] On the other hand, the trigeminal REZ lesion in the pontine infarction is not only linear but also wedge-shaped, and its size is relatively larger than that of MS. In addition, pontine infarction is relatively older at symptom onset and has more history of vascular risk factors than MS.[7] Although the pontine trigeminal REZ lesion is not specific to MS, it may provide further clues to the diagnosis of MS when combined with other MS typical clinical events.{Figure 1}{Figure 2}

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1Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011;69:292-302.
2da Silva CJ, da Rocha AJ, Mendes MF, Maia AC, Jr., Braga FT, Tilbery CP. Trigeminal involvement in multiple sclerosis: Magnetic resonance imaging findings with clinical correlation in a series of patients. Mult Scler 2005;11:282-5.
3Mills RJ, Young CA, Smith ET. Central trigeminal involvement in multiple sclerosis using high-resolution MRI at 3 T. Br J Radiol 2010;83:493-8.
4Gass A, Kitchen N, MacManus DG, Moseley IF, Hennerici MG, Miller DH. Trigeminal neuralgia in patients with multiple sclerosis: Lesion localization with magnetic resonance imaging. Neurology 1997;49:1142-4.
5Nakashima I, Fujihara K, Kimpara T, Okita N, Takase S, Itoyama Y. Linear pontine trigeminal root lesions in multiple sclerosis: Clinical and magnetic resonance imaging studies in 5 cases. Arch Neurol 2001;58:101-4.
6Kim JB, Yu S. Neurological picture. Trigeminal neuralgia after pontine infarction affecting the ipsilateral trigeminal nerve. J Neurol Neurosurg Psychiatry 2013;84:881-2.
7Renard D, Le Floch A, Aerts C, Freitag C, Pereira F. Intrapontine root entry zone FLAIR hyperintensity in classical trigeminal neuralgia. Headache 2014;54:1543-4.