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CASE REPORT
Year : 2018  |  Volume : 66  |  Issue : 7  |  Page : 135--137

Implications of secondary unresponsiveness to dopaminergic drugs with preserved response to subthalamic nucleus stimulation in Parkinson's disease

Abhishek Lenka1, Ketan R Jhunjhunwala1, Albert Stezin1, M Manjunath2, Dwarakanath Srinivas3, Ravi Yadav5, Pramod K Pal5 
1 Department of Clinical Neurosciences; Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
2 Department of Clinical Neurosciences, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
3 Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India

Correspondence Address:
Dr. Pramod K Pal
Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bengaluru - 560 029, Karnataka
India

Improvement in motor symptoms with levodopa is one of the hallmark features of Parkinson's disease (PD). The response to levodopa may reduce during the course of the illness. Few studies have also reported reduced response to levodopa in patients with PD several years after deep brain stimulation (DBS) of the subthalamic nucleus (STN) on both the sides. In this study, we report an extreme unresponsiveness to levodopa in the presence of a good response to STN stimulation in a patient 5 years after the DBS proceudre had been carried out. The implications of this phenomenon are also discussed.


How to cite this article:
Lenka A, Jhunjhunwala KR, Stezin A, Manjunath M, Srinivas D, Yadav R, Pal PK. Implications of secondary unresponsiveness to dopaminergic drugs with preserved response to subthalamic nucleus stimulation in Parkinson's disease.Neurol India 2018;66:135-137


How to cite this URL:
Lenka A, Jhunjhunwala KR, Stezin A, Manjunath M, Srinivas D, Yadav R, Pal PK. Implications of secondary unresponsiveness to dopaminergic drugs with preserved response to subthalamic nucleus stimulation in Parkinson's disease. Neurol India [serial online] 2018 [cited 2021 Jun 13 ];66:135-137
Available from: https://www.neurologyindia.com/article.asp?issn=0028-3886;year=2018;volume=66;issue=7;spage=135;epage=137;aulast=Lenka;type=0