ORIGINAL ARTICLE |
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| Year : 2010 | Volume
: 58
| Issue : 1 | Page : 29--34 |
Conditional downregulation of brain- derived neurotrophic factor and tyrosine kinase receptor B blocks epileptogenesis in the human temporal lobe epilepsy hippocampus
Xiaohua Hou, Xiaoran Wang, Liming Zhang
Department of Neurology, The First Affiliated Hospital of Harbin Medical University, China
Correspondence Address:
Liming Zhang
Department of Neurology, The First Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin, Heilongjiang - 150 001
China
Background : Brain-derived neurotrophic factor (BDNF) has been implicated as a potential therapeutic target in temporal lobe epilepsy (TLE). However, whether BDNF exerts an epileptogenic or antiepileptogenic function remains controversial. Materials and Methods : BDNF/tyrosine kinase receptor B (trkB) expression levels were comparatively assessed in the hippocampal tissue of TLE patients with (HS group) and without hippocampal sclerosis (non-HS group) as well as from non-epileptic controls. Results : Immunohistochemistry and immunoblot analysis revealed a marked increase in BDNF/trkB expression in the dentate gyrus and CA3 regions of HS and non-HS groups. The lack of any differences in expression levels was observed between HS and non-HS patients. Meanwhile, treatment with VPA (Valproic acid, anti-epileptic drug) resulted in a significant down-regulation of BDNF/trkB protein expression in sclerotic and non-sclerotic hippocampus (P < 0.001). In contrast, no marked change was noticed in VPA-untreated and OA-treated groups (sodium octanoate). Conclusion : These results suggest that the up-regulation of BDNF/trkB pathway might be at least in part responsible for the epileptogenesis.
How to cite this article:
Hou X, Wang X, Zhang L. Conditional downregulation of brain- derived neurotrophic factor and tyrosine kinase receptor B blocks epileptogenesis in the human temporal lobe epilepsy hippocampus.Neurol India 2010;58:29-34
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How to cite this URL:
Hou X, Wang X, Zhang L. Conditional downregulation of brain- derived neurotrophic factor and tyrosine kinase receptor B blocks epileptogenesis in the human temporal lobe epilepsy hippocampus. Neurol India [serial online] 2010 [cited 2023 Sep 28 ];58:29-34
Available from: https://www.neurologyindia.com/article.asp?issn=0028-3886;year=2010;volume=58;issue=1;spage=29;epage=34;aulast=Hou;type=0 |
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