ORIGINAL ARTICLE |
|
| Year : 2004 | Volume
: 52
| Issue : 4 | Page : 463--465 |
Adult-onset epilepsy and history of childhood febrile seizures: A retrospective study
Mohammad R Mohebbi1, Reza Navipour1, Mojdeh SeyedKazemi2, Hadi Zamanian1, Fatemeh Khamseh2
1 Department of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Neurology, Faculty of Medicine, Tehran Azad University, Tehran, Iran
Correspondence Address:
Mohammad R Mohebbi
No. 37, East Zamzam St., Abouzar Blvd., Pirouzi Ave., 17787, Tehran
Iran
BACKGROUND: Children with febrile seizures (FS) are at higher risk of developing epilepsy. There is robust literature on epilepsy with onset in childhood following FS but very little on the same issue in adults. AIMS: We intended to assess the association between adult-onset epilepsy and history of childhood FS. SETTINGS: The neurology clinic of a university hospital. DESIGN: A retrospective study. MATERIALS AND METHODS: Records of 101 consecutive adults (>14 years old) who were referred to our hospital with adult-onset seizures were reviewed and the patients and their families were interviewed to assess the medical history. STATISTICAL ANALYSIS: Chi-square test and Mantel-Haenszel method. RESULTS: Of the 101 patients, 9 were excluded for reasons of bacterial meningitis, recent head trauma, brain tumor, tricyclic antidepressants«SQ» overdose and missing reliable data of the childhood FS event. Thirty-one (33.7%) of the remaining 92 patients had history of FS in the childhood (71% men). Localization-related epilepsies were significantly associated with history of FS [Odds ratio: 3.29; (95% CI, 1.30-8.06)] ( ²= 5.49, df = 1, P=0.012) when compared to other epilepsies and epilepsy syndromes. An initial unprovoked simple partial seizure was also significantly associated with a positive history of FS [Odds ratio: 8.05; (95% CI 2.88-22.45)] ( ²= 15.86, df = 1, P<0.001). CONCLUSIONS: Localization-related epilepsies and partial seizures seem to be associated with a history of FS in childhood. This warrants more investigation to understand the mechanism as well as a possible pathology common in both localization-related epilepsies and FS in the affected probands.
How to cite this article:
Mohebbi MR, Navipour R, SeyedKazemi M, Zamanian H, Khamseh F. Adult-onset epilepsy and history of childhood febrile seizures: A retrospective study
.Neurol India 2004;52:463-465
|
How to cite this URL:
Mohebbi MR, Navipour R, SeyedKazemi M, Zamanian H, Khamseh F. Adult-onset epilepsy and history of childhood febrile seizures: A retrospective study
. Neurol India [serial online] 2004 [cited 2023 Mar 23 ];52:463-465
Available from: https://www.neurologyindia.com/article.asp?issn=0028-3886;year=2004;volume=52;issue=4;spage=463;epage=465;aulast=Mohebbi;type=0 |
|
