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ORIGINAL ARTICLE
Year : 2004  |  Volume : 52  |  Issue : 1  |  Page : 82--86

Clinico-pathological study of cerebral aneurysms

BJ Rajesh1, S Sandhyamani2, RN Bhattacharya1 
1 Departments of Neurosurgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India
2 Departments of Pathology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India

Correspondence Address:
B J Rajesh
Departments of Neurosurgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum
India

Aims and Objectives: A clinico-pathological study of cerebral aneurysms was undertaken to understand the histopathogical nature of the lesions and to ascertain possible etiological risk factors. Material and Methods: Of the 255 cases of cerebral aneurysms operated upon at our Institute during the two-year period between Jan 1999 to Dec 2000, a detailed study was conducted on 57 cases where the aneurysm sac could be excised and subjected to histopathological examination. Aneurysm sacs were fixed in 10% buffered formaldehyde and processed through graded alcohol. Paraffin-embedded sections were examined, using hematoxylin and eosin, Verhoeff van Giesonís and toluidine blue staining techniques. Histopathological observations were analyzed and correlated with clinical features. Results: The ages of the patients ranged from 17-65 years and there were 33 males and 24 females. Twenty-six patients were chronic smokers and 19 patients had hypertension. There were 54 saccular and 3 fusiform aneurysms, predominantly involving the anterior circulation (52 cases) than posterior circulation (5 cases). In 35 cases, histopathological studies demonstrated mucoid deposits between hyperplastic cellular elements in the true and false aneurysm wall and/or parent artery or vasavasora. The changes were associated with dystrophic changes in the internal elastic lamina. Conclusion: Besides significant risk factors like smoking and hypertension, such mucoid vasculopathic changes may have predisposed vessels to structural weakness and aneurysm formation in our patients.


How to cite this article:
Rajesh B J, Sandhyamani S, Bhattacharya R N. Clinico-pathological study of cerebral aneurysms.Neurol India 2004;52:82-86


How to cite this URL:
Rajesh B J, Sandhyamani S, Bhattacharya R N. Clinico-pathological study of cerebral aneurysms. Neurol India [serial online] 2004 [cited 2021 Sep 24 ];52:82-86
Available from: https://www.neurologyindia.com/article.asp?issn=0028-3886;year=2004;volume=52;issue=1;spage=82;epage=86;aulast=Rajesh;type=0