REVIEW ARTICLE |
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| Year : 2003 | Volume
: 51
| Issue : 4 | Page : 455--460 |
Botulinum toxins: Pharmacology and its current therapeutic evidence for use
UB Muthane, JN Panikar
Department of Neurology NIMHANS Hosur Road, Bangalore - 560029, India
Correspondence Address:
U B Muthane
Department of Neurology NIMHANS Hosur Road, Bangalore - 560029
India
Botulinum toxins are, as a group, among the most potent neuromuscular toxins known, yet they are clinically useful in the management of conditions associated with muscular and glandular over-activity. Botulinum toxins act by preventing release of acetylcholine into the neuromuscular junction. While botulinum toxin type A is commonly available, different manufacturers produce specific products, which are not directly interchangeable and should not be considered as generically equivalent formulations. Type B is also available in the market. Each formulation of botulinum toxin is unique with distinct dosing, efficacy and safety profiles for each use to which it is applied. Botulinum toxin type A is the treatment of choice based on its depth of evidence in dystonias and most other conditions. Botulinum toxin type A is established as useful in the management of spasticity, tremors, headache prophylaxis and several other neurological conditions. Active research is underway to determine the parameters for which the type B toxin can be used in these conditions, as covered in this review. Botulinum toxin use has spread to several fields of medicine.
How to cite this article:
Muthane U B, Panikar J N. Botulinum toxins: Pharmacology and its current therapeutic evidence for use.Neurol India 2003;51:455-460
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How to cite this URL:
Muthane U B, Panikar J N. Botulinum toxins: Pharmacology and its current therapeutic evidence for use. Neurol India [serial online] 2003 [cited 2023 Dec 11 ];51:455-460
Available from: https://www.neurologyindia.com/article.asp?issn=0028-3886;year=2003;volume=51;issue=4;spage=455;epage=460;aulast=Muthane;type=0 |
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