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Year : 2003  |  Volume : 51  |  Issue : 1  |  Page : 43--48

Bilateral subthalamic nucleus stimulation for Parkinson´┐Żs disease

PK Doshi, NA Chhaya, MH Bhatt 
 Jaslok Hospital and Research Centre, Mumbai., India

Correspondence Address:
P K Doshi
aslok Hospital and Research Centre, Mumbai.

High frequency stimulation of the subthalamic nucleus (STN) is known to ameliorate the signs and symptoms of advanced Parkinson´┐Żs disease. Aim: We studied the effect of high frequency STN stimulation in 23 patients. Method: Twenty-three patients suffering from severe Parkinson´┐Żs disease (Stages III-V on Hoehn and Yahr scale) and, particularly bradykinesia, rigidity, and levodopa-induced dyskinesias underwent bilateral implantation of electrodes in the STN. Preoperative and postoperative assessments of these patients at 1, 3, 6 and 12 months follow-up, in ´┐Żon´┐Ż and ´┐Żoff´┐Ż drug conditions, was carried out using Unified Parkinson´┐Żs Disease Rating Scale, Hoehn and Yahr staging, England activities of daily living score and video recordings. Results: After one year of electrical stimulation of the STN, the patients´┐Ż scores for activities of daily living and motor examination scores (Unified Parkinson´┐Żs Disease Rating Scale parts II and III) off medication improved by 62% and 61% respectively (p<0.0005). The subscores for the akinesia, rigidity, tremor and gait also improved. (p<0.0005). The average levodopa dose decreased from 813 mg to 359 mg. The cognitive functions remained unchanged. Two patients developed device-related complications and two patients experienced abnormal weight gain. Conclusion: Bilateral subthalamic nucleus stimulation is an effective treatment for advanced Parkinson´┐Żs disease. It reduces the severity of ´┐Żoff´┐Ż phase symptoms, improves the axial symptoms and reduces levodopa requirements. The reduction in the levodopa dose is useful in controlling drug-induced dyskinesias.

How to cite this article:
Doshi P K, Chhaya N A, Bhatt M H. Bilateral subthalamic nucleus stimulation for Parkinson´┐Żs disease .Neurol India 2003;51:43-48

How to cite this URL:
Doshi P K, Chhaya N A, Bhatt M H. Bilateral subthalamic nucleus stimulation for Parkinson´┐Żs disease . Neurol India [serial online] 2003 [cited 2023 Jun 7 ];51:43-48
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