Bilateral subthalamic nucleus stimulation for Parkinsonï¿½s disease :<b>PK Doshi, NA Chhaya, MH Bhatt</b>, Neurololy India

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ORIGINAL ARTICLE

Year : 2003 | Volume : 51 | Issue : 1 | Page : 43--48

Bilateral subthalamic nucleus stimulation for Parkinsonï¿½s disease

PK Doshi, NA Chhaya, MH Bhatt
Jaslok Hospital and Research Centre, Mumbai., India

Correspondence Address:
P K Doshi
aslok Hospital and Research Centre, Mumbai.
India

High frequency stimulation of the subthalamic nucleus (STN) is known to ameliorate the signs and symptoms of advanced Parkinsonï¿½s disease. Aim: We studied the effect of high frequency STN stimulation in 23 patients. Method: Twenty-three patients suffering from severe Parkinsonï¿½s disease (Stages III-V on Hoehn and Yahr scale) and, particularly bradykinesia, rigidity, and levodopa-induced dyskinesias underwent bilateral implantation of electrodes in the STN. Preoperative and postoperative assessments of these patients at 1, 3, 6 and 12 months follow-up, in ï¿½onï¿½ and ï¿½offï¿½ drug conditions, was carried out using Unified Parkinsonï¿½s Disease Rating Scale, Hoehn and Yahr staging, England activities of daily living score and video recordings. Results: After one year of electrical stimulation of the STN, the patientsï¿½ scores for activities of daily living and motor examination scores (Unified Parkinsonï¿½s Disease Rating Scale parts II and III) off medication improved by 62% and 61% respectively (p<0.0005). The subscores for the akinesia, rigidity, tremor and gait also improved. (p<0.0005). The average levodopa dose decreased from 813 mg to 359 mg. The cognitive functions remained unchanged. Two patients developed device-related complications and two patients experienced abnormal weight gain. Conclusion: Bilateral subthalamic nucleus stimulation is an effective treatment for advanced Parkinsonï¿½s disease. It reduces the severity of ï¿½offï¿½ phase symptoms, improves the axial symptoms and reduces levodopa requirements. The reduction in the levodopa dose is useful in controlling drug-induced dyskinesias.

How to cite this article:
Doshi P K, Chhaya N A, Bhatt M H. Bilateral subthalamic nucleus stimulation for Parkinsonï¿½s disease .Neurol India 2003;51:43-48

How to cite this URL:
Doshi P K, Chhaya N A, Bhatt M H. Bilateral subthalamic nucleus stimulation for Parkinsonï¿½s disease . Neurol India [serial online] 2003 [cited 2023 Jun 7 ];51:43-48
Available from: https://www.neurologyindia.com/article.asp?issn=0028-3886;year=2003;volume=51;issue=1;spage=43;epage=48;aulast=Doshi;type=0