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Year : 1999  |  Volume : 47  |  Issue : 3  |  Page : 196--201

Pathology of temporal lobe epilepsy : An analysis of 100 consecutive surgical specimens from patients with medically refractory epilepsy.

V Radhakrishnan, MB Rao, K Radhakrishnan, SV Thomas, DS Nayak, B Santoshkumar, E Joseph, B Raghunath 
 Department of Pathology, Sree Chitra Tirunal Institute of Medical Sciences and Technology, Trivandrum, Kerala, 695011, India., India

Correspondence Address:
V Radhakrishnan
Department of Pathology, Sree Chitra Tirunal Institute of Medical Sciences and Technology, Trivandrum, Kerala, 695011, India.
India

The neuropathological features of temporal lobe epilepsy were studied utilising 100 consecutive surgical specimens from patients with medically refractory complex partial seizures. A wide spectrum of neuropathological changes was recorded in 98 specimens. Fifty-eight specimens showed features of Ammon«SQ»s horn sclerosis. Diffuse accumulation of corpora amylacea were demonstrated in the resected temporal lobes from 54 patients. Six patients had neoplastic lesions of temporal lobe. One unique case of dysembryoplastic neuroepithelial tumour showed a melanotic component within the tumour. The neuropathological features were regarded as nonspecific in 31% of cases. Our results indicate that a majority of patients with medically intractable epilepsy of temporal lobe origin reveal significant neuropathological features. Careful documentation of the neuropathological features and its correlation with radiological, electrophysiological and pre- and post-surgical clinical features will help in predicting the seizure outcome after temporal lobectomy for medically refractory epilepsy.


How to cite this article:
Radhakrishnan V, Rao M B, Radhakrishnan K, Thomas S V, Nayak D S, Santoshkumar B, Joseph E, Raghunath B. Pathology of temporal lobe epilepsy : An analysis of 100 consecutive surgical specimens from patients with medically refractory epilepsy. Neurol India 1999;47:196-201


How to cite this URL:
Radhakrishnan V, Rao M B, Radhakrishnan K, Thomas S V, Nayak D S, Santoshkumar B, Joseph E, Raghunath B. Pathology of temporal lobe epilepsy : An analysis of 100 consecutive surgical specimens from patients with medically refractory epilepsy. Neurol India [serial online] 1999 [cited 2021 Oct 18 ];47:196-201
Available from: https://www.neurologyindia.com/article.asp?issn=0028-3886;year=1999;volume=47;issue=3;spage=196;epage=201;aulast=Radhakrishnan;type=0