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Year : 1998  |  Volume : 46  |  Issue : 3  |  Page : 229--231

Influence of kinnow juice on the bioavailability of carbamazepine in healthy male volunteers.

SK Garg, VK Bhargava, H James, N KuJan-Mar, S Prabhakar, KuJan-Mar Naresh 
 Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012, India

Correspondence Address:
SK Garg
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012
India

Kinnow juice produces a marked and variable increase in carbamazepine bioavailability. The pharmacokinetics of carbamazepine was studied after drug administration with 300 ml water or kinnow juice in a randomized cross over trial on nine healthy male volunteers. With kinnow juice peak serum concentration (Cmax) and area under the serum concentration time curve (AUC) was significantly (P < 0.05) increased and time to reach peak serum concentration (tmax) was significantly decreased (p < 0.05) as compared with water. No change was observed in the elimination half life (t1/2) of drug. The mechanism by which kinnow juice enhances carbamazepine bioavailability could be due to inhibition of cytochrome P-450 enzyme, since kinnow juice contains naringin which is considered to be inhibitor of liver microsomal dihydropyridine oxidation.


How to cite this article:
Garg S, Bhargava V, James H, KuJan-Mar N, Prabhakar S, Naresh KM. Influence of kinnow juice on the bioavailability of carbamazepine in healthy male volunteers. Neurol India 1998;46:229-231


How to cite this URL:
Garg S, Bhargava V, James H, KuJan-Mar N, Prabhakar S, Naresh KM. Influence of kinnow juice on the bioavailability of carbamazepine in healthy male volunteers. Neurol India [serial online] 1998 [cited 2021 Oct 25 ];46:229-231
Available from: https://www.neurologyindia.com/article.asp?issn=0028-3886;year=1998;volume=46;issue=3;spage=229;epage=231;aulast=Garg;type=0