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Year : 1997  |  Volume : 45  |  Issue : 3  |  Page : 171--181

Leigh俟Q製 disease : analysis of clinical and imaging characteristics with possible therapeutic implications.

S Pradhan, D Ghosh, S KuJan-Mar 
 Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow - 226 014, India

Correspondence Address:
S Pradhan
Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow - 226 014
India

The symptoms and signs of Leigh俟Q製 disease are so variable that the diagnosis is extremely difficult. The disease was so far being confirmed only at autopsy. Antemortem clinical diagnosis, however, is important, as some of these patients may respond to high dose of vitamin B-1. We report two patients of Leigh俟Q製 disease suspected clinically and confirmed on MR imaging. Both the patients responded partially to parenteral thiamine and subsequently remained stable on convenient oral dosage during one year of observation. Follow-up MRI done on patient showed resolution of some of the lesions, no change in some and appearance of some new lesions. There was no definite correlation between the thiamine related clinical recovery and the structural changes observed on MRI. The extreme rarity of involvement of medulla and cervical spinal cord as observed in one of the patients and of external capsule as seen in the other patient, is highlighted.


How to cite this article:
Pradhan S, Ghosh D, KuJan-Mar S. Leigh's disease : analysis of clinical and imaging characteristics with possible therapeutic implications. Neurol India 1997;45:171-181


How to cite this URL:
Pradhan S, Ghosh D, KuJan-Mar S. Leigh's disease : analysis of clinical and imaging characteristics with possible therapeutic implications. Neurol India [serial online] 1997 [cited 2021 Oct 19 ];45:171-181
Available from: https://www.neurologyindia.com/article.asp?issn=0028-3886;year=1997;volume=45;issue=3;spage=171;epage=181;aulast=Pradhan;type=0