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Year : 2022  |  Volume : 70  |  Issue : 4  |  Page : 1668--1669

Cerebrospinal Fluid Biomarkers for Monitoring Delayed Neurologic Sequelae after Carbon Monoxide Poisoning

Health Service Center, Saitama University, Saitama-shi, Japan

Correspondence Address:
Tsubasa Omi
Saitama university, Saitama-shi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.355093

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Delayed neuropsychiatric sequelae (DNS), which are related to neuropsychiatric symptoms and severe sequelae, occur within a few days of recovery from acute poisoning. They may involve a slowly progressing demyelinating white matter lesion caused by carbon monoxide cytotoxicity; moreover, the involvement of immune mechanisms has been reported. However, there remains no established treatment or therapeutic gain factors. A 29-year-old man with DNS who experienced carbon monoxide poisoning underwent corticosteroid therapy with concomitant measurements of cerebrospinal fluid levels of MBP, IL-6, and pNF-H. Treatment led to an improvement in symptoms and lesions on magnetic resonance imaging. Corticosteroid therapy and monitoring can be used to treat and monitor DNS.


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Online since 20th March '04
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