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Year : 2022  |  Volume : 70  |  Issue : 4  |  Page : 1639--1642

Intracranial Myxoid Mesenchymal Tumour with EWSR1-ATF1 Fusion Sans Myxoid Stroma – Report of A Newer Entity with Brief Review of Literature

Department of Neurosurgery, University Hospital Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX, United Kingdom

Correspondence Address:
Salman T Shaikh
University Hospital Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX
United Kingdom
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.355080

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Intracranial myxoid mesenchymal tumors (IMMTs) are a relatively new group of tumors, first described in 2017. We report this rare variant in a 27-year-old female which was initially suspected to be a high-grade glial neoplasm. Next-generation sequencing confirmed the presence of fusion between the FET and cAMP response element-binding (CREB) family of genes. This fusion is diagnostic of IMMT, with only 19 such cases reported so far. The authors would like to highlight the need for genomic sequencing for the diagnosis of this tumor, its propensity to recur locally, and its relatively better prognosis as compared to high-grade gliomas.


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Online since 20th March '04
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