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Year : 2021  |  Volume : 69  |  Issue : 6  |  Page : 1688--1692

The Cognitive Characteristics of PNE Children with Different Genders: A Resting-State fMRI Study

Department of Pediatrics, Changzhou Children's Hospital of Nantong University, Changzhou, China

Correspondence Address:
Dr. Aibin Zheng
Department of Pediatrics, Changzhou Children's Hospital of Nantong University, Changzhou - 213 000
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.333504

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Objectives: To study the brain mechanism and behavioral performance of cognitive functional differences between children with primary nocturnal enuresis (PNE) of different genders by resting-state functional magnetic resonance imaging (rs-fMRI) and attention behavior research. Methods: All the children participating the test were 5–11 years old including 32 PNE children (15 boys and 17 girls) and 35 normal children (16 boys and 19 girls). They respectively went through MRI scan and the data were analyzed by the method of amplitude of low frequency fluctuation (ALFF). Then continuous performance test (CPT) was done and the correct number and reaction time were recorded. The between-group variance was analyzed by two sample t-test. Results: 1. fMRI: There were no obviously different brain regions of ALFF between normal boys and girls. The brain regions which had obvious differences of ALFF between PNE boys and girls were right middle frontal gyrus, left inferior parietal lobule and right posterior cerbellar lobe. And the group of PNE boys were higher than PNE girls on all the three regions (P < 0.05). 2. CPT: The reaction time of PNE and normal boys was both lower than those of girls, but there were no obvious differences on the correct number. Conclusion: This study found that girls with PNE performed more obvious damages on attention, executive function and working memory than boys which might be related to the fact that girls were more likely to suffer from confidence impairment due to enuresis leading to cognitive dysfunctions. The method of ALFF based on resting-state fMRI provided a new approach for studying the cognitive characteristics of PNE children.


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Online since 20th March '04
Published by Wolters Kluwer - Medknow