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Table of Contents    
CORRESPONDENCE
Year : 2021  |  Volume : 69  |  Issue : 4  |  Page : 1142

Bone Mineral Density and Serum Vitamin D Status in Parkinson's Disease: Are the Stage and Clinical Features of the Disease Important?


Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq

Date of Submission17-May-2020
Date of Decision25-Aug-2020
Date of Acceptance15-May-2021
Date of Web Publication2-Sep-2021

Correspondence Address:
Mahmood Dhahir Al-Mendalawi
P.O. Box 55302, Baghdad Post Office, Baghdad
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.325366

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How to cite this article:
Al-Mendalawi MD. Bone Mineral Density and Serum Vitamin D Status in Parkinson's Disease: Are the Stage and Clinical Features of the Disease Important?. Neurol India 2021;69:1142

How to cite this URL:
Al-Mendalawi MD. Bone Mineral Density and Serum Vitamin D Status in Parkinson's Disease: Are the Stage and Clinical Features of the Disease Important?. Neurol India [serial online] 2021 [cited 2021 Sep 18];69:1142. Available from: https://www.neurologyindia.com/text.asp?2021/69/4/1142/325366




It is worthy to comment on the interesting case-control study by Ozturk et al.[1] published in March–April 2020 issue of the Neurology India. On employing dual-energy X-ray absorptiometry (DEXA), Ozturk et al.[1] found that lumbar and femoral bone mineral density (BMD) levels were lower significantly in Turkish patients with Parkinson's disease (PD) in comparison with controls. The low BMD values were detected in the early stages of the PD (stage 1 and 1.5) and were marked by the progress of the disease. There was a negative correlation between BMD and the clinical pictures of the PD.[1] Ozturk et al.[1] recommended that all PD patients must be screened for developing osteoporosis in the early stages of the disease. Besides a few study limitations mentioned by Ozturk et al.,[1] I presume that the following methodological limitation is relevant. It is obvious that BMD reference values (BMDRV) are needed to interpret BMD values estimated by DEXA. Since BMDRV is determined by different factors, notably age, gender, race, weight, pubertal stage, and socioeconomic class,[2],[3] normative BMDRV has been formulated for certain populations to be utilized in the researches centers and clinical settings.[4] Turkey is among pioneer countries that have already generated their BMDRV.[5] Regrettably, Ozturk et al.[1] didn't address in the study methodology which BMDRV they employed to evaluate the calculated BMD levels. Hence, this limitation might bring into question the correctness of the study findings and recommendations addressed by Ozturk et al.[1]

Financial support and sponsorship

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Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Ozturk EA, Gundogdu I, Tonuk B, Umay E, Kocer BG, Cakci A. Bone mineral density and serum vitamin D status in Parkinson's Disease: Are the stage and clinical features of the disease important? Neurol India 2020;68:394-400.  Back to cited text no. 1
[PUBMED]  [Full text]  
2.
Arabi A, Nabulsi M, Maalouf J, Choucair M, Khalifé H, Vieth R, et al. Bone mineral density by age, gender, pubertal stages, and socioeconomic status in healthy Lebanese children and adolescents. Bone 2004;35:1169-79.  Back to cited text no. 2
    
3.
Wu Q, Lefante JJ, Rice JC, Magnus JH. Age, race, weight, and gender impact normative values of bone mineral density. Gend Med 2011;8:189-201.  Back to cited text no. 3
    
4.
Cui LH, Choi JS, Shin MH, Kweon SS, Park KS, Lee YH, et al. Prevalence of osteoporosis and reference data for lumbar spine and hip bone mineral density in a Korean population. J Bone Miner Metab 2008;26:609-17.  Back to cited text no. 4
    
5.
Manisali M, Ozaksoy D, Yilmaz E, Senocak O, Tatari H, Baran O, et al. Bone mineral density reference values in the normal female and male population of Izmir, Turkey. Eur Radiol 2003;13:157-62.  Back to cited text no. 5
    




 

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