Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 4873  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 »   Next article
 »   Previous article
 »   Table of Contents

 Resource Links
 »   Similar in PUBMED
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded23    
    Comments [Add]    

Recommend this journal


Year : 2021  |  Volume : 69  |  Issue : 3  |  Page : 681--685

Role of Viral Infections in Multiple Sclerosis Pathogenesis among Indian Population

Center for Advanced Neurological Research, K S Hegde Medical Academy, Nitte, (Deemed to be University), Mangalore, Karnataka, India

Correspondence Address:
Dr. Lekha Pandit
Director of Center for Advanced Neurological Research, KS Hegde Medical Academy, Nitte (Deemed to be University), Mangalore - 575 018, Karnataka
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.319209

Rights and Permissions

Background: The role of viral infections in multiple sclerosis (MS) pathogenesis is unclear. Objective: Certain neurotropic viruses previously linked with MS among white population were studied including Epstein–Barr virus, human herpesvirus-6 (HHV-6) and MS-associated retrovirus (MSRV). Material and Methods: Sixty-two MS patients (37 had a recent clinical relapse) and 65 controls with other neurological disorders were included. Blood and cerebrospinal fluid (CSF) samples were obtained and processed with the primary objective of determining whether there was intrathecal multiplication of viruses under study (EBV, HHV6 A and B and human endogenous retrovirus) or a breach in blood–brain barrier associated with viral presence in both peripheral blood and CSF. Results: Evidence of breach in blood–brain barrier was seen in 86.5% of patients as evidenced by abnormal CSF/serum albumin index and or MRI. EBV nuclear antigen (EBNA1 IgG) was seen in 89% of MS patients and 58% controls (P = <0.001). However, HHV6 IgG was similar in both groups (85% versus 81%; P = 0.45). In affinity immunoblotting reaction intrathecal IgG synthesis against EBNA1 antigen was demonstrable in 26% (16/62) of patients and none against HHV6. A subset of patients showed significant elevation in mean copy number of plasma EBV DNA during relapse and there was a trend for the same among patients harboring HHV-6B. No evidence of isolated intrathecal viral presence or multiplication was seen. Conclusions: The results of our study suggest that viruses studied namely EBV and HHV6 have a role in triggering relapses through a peripheral mechanism, rather than a direct role through intrathecal multiplication.


Print this article     Email this article

Online since 20th March '04
Published by Wolters Kluwer - Medknow