| ORIGINAL ARTICLE
|Year : 2021 | Volume
| Issue : 1 | Page : 75--80
Ischemia Modified Albumin and miR-126 Play Important Role in Diagnosis of Posterior Circulation Transient Ischemic Attack and Prediction of Secondary Cerebral Infarction
Ding Lidong1, Xiao Zhanghong1, Mao Huawu1, Hang Xiaofang1, Guo Junhua1, Ke Kaifu2, Chen Jue3
1 Department of Neurology, Taizhou Second People's Hospital, Jiangyan District, Taizhou, Jiangsu Province, China
2 Department of Neurology, Affiliated Hospital of Nantong University, Nantong, China
3 Department of Oncology, Medicine and Pharmaceutical Research Institution, Yangzhou University, Yangzhou, Jiangsu Province, China
Background: Transient ischemic attack (TIA) is a super warning for cerebral infarction stroke, thus probe of sensitive biomarker for TIA diagnosis and prognosis can contribute to make an optimal intervention plan.
Objective: This study was conducted to explore the value of ischemic modified albumin (IMA) and microRNA-12miR-126 on the diagnosis of posterior circulation TIA and the prediction of secondary cerebral infarction.
Study Design: This study was conducted as a longitudinal prospective research.
Methods: The levels of serum IMA and miR-126 at 3h, 6h and 12h after TIA onset were analyzed in 106 patients, then the predictive value of IMA and miR-126 for secondary cerebral infarction were tested.
Results: A significant increase of serum IMA and a decrease of miR-126 were observed after TIA onset (P = 0.000),simultaneously a significant negative correlation was found between serum IMA for 3 h and miR-126 for 12 hr=-0.401, P = 0.000. Both IMA and miR-126 were significant associated with the secondary cerebral infarction.
Conclusion: Early detection of IMA and miR-126 is of great value in diagnosing posterior circulation TIA and predicting the secondary cerebral infarction.
Department of Neurology, Taizhou Second People's Hospital, No. 27, Jiankang Road, Jiangyan District, Taizhou - 225500, Jiangsu Province
Source of Support: None, Conflict of Interest: None
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