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Year : 2021  |  Volume : 69  |  Issue : 1  |  Page : 75--80

Ischemia Modified Albumin and miR-126 Play Important Role in Diagnosis of Posterior Circulation Transient Ischemic Attack and Prediction of Secondary Cerebral Infarction

1 Department of Neurology, Taizhou Second People's Hospital, Jiangyan District, Taizhou, Jiangsu Province, China
2 Department of Neurology, Affiliated Hospital of Nantong University, Nantong, China
3 Department of Oncology, Medicine and Pharmaceutical Research Institution, Yangzhou University, Yangzhou, Jiangsu Province, China

Correspondence Address:
Ding Lidong
Department of Neurology, Taizhou Second People's Hospital, No. 27, Jiankang Road, Jiangyan District, Taizhou - 225500, Jiangsu Province
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.310100

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Background: Transient ischemic attack (TIA) is a super warning for cerebral infarction stroke, thus probe of sensitive biomarker for TIA diagnosis and prognosis can contribute to make an optimal intervention plan. Objective: This study was conducted to explore the value of ischemic modified albumin (IMA) and microRNA-12miR-126 on the diagnosis of posterior circulation TIA and the prediction of secondary cerebral infarction. Study Design: This study was conducted as a longitudinal prospective research. Methods: The levels of serum IMA and miR-126 at 3h, 6h and 12h after TIA onset were analyzed in 106 patients, then the predictive value of IMA and miR-126 for secondary cerebral infarction were tested. Results: A significant increase of serum IMA and a decrease of miR-126 were observed after TIA onset (P = 0.000),simultaneously a significant negative correlation was found between serum IMA for 3 h and miR-126 for 12 hr=-0.401, P = 0.000. Both IMA and miR-126 were significant associated with the secondary cerebral infarction. Conclusion: Early detection of IMA and miR-126 is of great value in diagnosing posterior circulation TIA and predicting the secondary cerebral infarction.


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Online since 20th March '04
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