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Year : 2020  |  Volume : 68  |  Issue : 8  |  Page : 268--277

Deep Brain Stimulation for Treatment of Refractory Epilepsy

1 Department of Neurosurgery, Epilepsy Surgery Program, Hospital Universitário Cajuru, Curitiba, Brazil
2 Department of Neurosurgery, Epilepsy Surgery Program, Clínica Cukiert, São Paulo, Brazil

Correspondence Address:
Dr. Tatiana von Hertwig Fernandes de Oliveira
1040, Silveira Peixoto, Batel, Curitiba-PR -80240120
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.302454

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Deep brain stimulation (DBS) has been used in the treatment of motor diseases with remarkable safety and efficacy, which abet the interest of its application in the management of other neurologic and psychiatric disorders such as epilepsy. Experimental data demonstrated that electric current could modulate distinct brain circuits and decrease the neuronal hypersynchronization seen in epileptic activity. The ability to carefully choose the most suitable anatomical target as well as to define the most reasonable stimulation parameters is highly dependable on the comprehension of the underlying mechanisms of action, which remain unclear. This review aimed to explore the relevant clinical data regarding the use of DBS in the treatment of refractory epilepsy.


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Online since 20th March '04
Published by Wolters Kluwer - Medknow