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|Year : 2020 | Volume
| Issue : 6 | Page : 1508
Neurocutaneous Melanosis: Cutaneous and Neuroimaging Findings
Harikrishnan Ramachandran, Ashalatha Radhakrishnan, Sunesh E Radhakrishnan
Department of Neurology, SCTIMST, Trivandrum, India
|Date of Web Publication||19-Dec-2020|
Dr. Ashalatha Radhakrishnan
Professor of Neurology, R. Madhavan Nayar Center for Comprehensive Epilepsy Care (RMNC), In-Charge, Comprehensive Center For Sleep Disorders (CCSD), Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), (An Institute of National Importance Under Department of Science & Technology, Government of India) Trivandrum - 695 011, Kerala
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Ramachandran H, Radhakrishnan A, Radhakrishnan SE. Neurocutaneous Melanosis: Cutaneous and Neuroimaging Findings. Neurol India 2020;68:1508
A 2-year-old boy presented with frequent complex partial seizures since two months of age and global developmental delay. He had classical cutaneous lesions of NCM [Figure 1]. NCM is a nonfamilial neurocutaneous syndrome of poor neurological prognosis. There are large cutaneous melanocytic naevi and CNS melanin deposits due to defective migration of melanoblasts from neural crest with frequently seen bathing suit pattern skin lesions. MRI shows bilateral amygdala T1 hyperintensities due to paramagnetic properties of melanin which is commonly described with NCM., In this context with the typical cutaneous and imaging findings, there are no other differential diagnosis.
|Figure 1: (a, b) Multiple large cutaneous naevi with satellite lesions (black arrows) in a cape shaped or bathing suit distribution. (c) Multiple satellite lesions with hypertrichosis. (d): Bilaterally symmetric T1 hyperintense lesions in amygdala (white arrows) in axial MRI brain|
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The authors thank Mr. Lijikumar G, Scientific officer, Medical Illustration who helped in obtaining high-quality images.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient (s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
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Conflicts of interest
There are no conflicts of interest.
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