Atormac
brintellex
Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 3496  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 Search
 
  
 Resource Links
  »  Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
  »  Article in PDF (748 KB)
  »  Citation Manager
  »  Access Statistics
  »  Reader Comments
  »  Email Alert *
  »  Add to My List *
* Registration required (free)  

 
  In this Article
 »  Abstract
 » Case Report
 » Discussion
 » Conclusion
 »  References
 »  Article Figures

 Article Access Statistics
    Viewed686    
    Printed6    
    Emailed0    
    PDF Downloaded17    
    Comments [Add]    

Recommend this journal

 


 
Table of Contents    
BRIEF REPORT
Year : 2020  |  Volume : 68  |  Issue : 6  |  Page : 1428-1430

Delayed Cerebral Infarction Following Trans-Sylvian Surgery for Craniopharyngioma Presenting as Status Epilepticus


1 Department of Neurosurgery, BR Life Kalinga Superspeciality Hospital, Bhubaneshwar, Odisha, India
2 Department of Neurology, BR Life Kalinga Superspeciality Hospital, Bhubaneshwar, Odisha, India
3 Department of Pediatrics, BR Life Kalinga Superspeciality Hospital, Bhubaneshwar, Odisha, India
4 Department of Critical Care Medicine, BR Life Kalinga Superspeciality Hospital, Bhubaneshwar, Odisha, India
5 Department of Radiology, BR Life Kalinga Superspeciality Hospital, Bhubaneshwar, Odisha, India

Date of Web Publication19-Dec-2020

Correspondence Address:
Dr. D K Satpathy
Consultant Neurosurgery, BR Life Kalinga Superspeciality Hospital, Bhubaneswar - 751 023, Odisha
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.304097

Rights and Permissions

 » Abstract 

The postoperative period after craniopharyngioma surgery has a high likelihood of complications and its management can be challenging. We present the case of a 10-year-old boy who was operated for craniopharyngioma. In the postoperative period he developed lacunar infarct, endocrine disturbances, delayed vasospasm leading to cerebral infarction and status epilepticus. The likely cause of status epilepticus was likely delayed cerebral infarction compounded with dyselectrolytemia. We discuss the possible etiology of delayed cerebral infarction.


Keywords: Craniopharyngioma, delayed vasospasm, endocrine complications, postoperative complications, status epilepticus
Key Messages: Delayed cerebral infarction due to vasospasm following pituitary surgery may present as status epilepticus. Symptoms of new stroke may be missed in patients who are deeply comatosed. There should be a high index of suspicion in such cases.


How to cite this article:
Satpathy D K, Mitra C, Samal P, Pattnaik S B, Mohanty B B, Acharya S D. Delayed Cerebral Infarction Following Trans-Sylvian Surgery for Craniopharyngioma Presenting as Status Epilepticus. Neurol India 2020;68:1428-30

How to cite this URL:
Satpathy D K, Mitra C, Samal P, Pattnaik S B, Mohanty B B, Acharya S D. Delayed Cerebral Infarction Following Trans-Sylvian Surgery for Craniopharyngioma Presenting as Status Epilepticus. Neurol India [serial online] 2020 [cited 2021 Jan 27];68:1428-30. Available from: https://www.neurologyindia.com/text.asp?2020/68/6/1428/304097




Delayed cerebral ischemia and infarction following surgery in the suprasellar cisterns are relatively rare. The cause is mostly vasospasm of the arteries of circle of Willis. The diagnosis is often missed unless the possibility is kept in mind. It leads to high morbidity and mortality. We present a case of delayed cerebral infarction following trans- sylvian surgery for craniopharyngioma manifesting as status epilepticus.


 » Case Report Top


A 10-year-old boy presented with history of gradual diminution of vision of 2 months duration. Examination revealed complete loss of vision in right eye with absent PL and PR and dilated pupil. Left eye had normal vision. His hormone levels were within normal limits. MRI revealed a cystic supra sellar tumor with compression of optic chiasma [Figure 1]a & [Figure 1]b. He underwent left pterional craniotomy and trans-sylvian approach for excision of tumor. The tumor was cystic with thick calcified wall. Dissection was carried out along the arachnoid plane, but the latter was lost towards the end. The tumor did not have much adhesion. It was ruptured to ease dissection – Machine oil type of fluid oozed out. Two bleeding perforators were coagulated. The whole tumor was removed. There was no obvious injury to major intracranial vessels.
Figure 1: (a & b) Preoperative MRI Brain showed space occupying lesion, hypointense on T1 and hyperintense on T2, suggestive of a cystic suprasellar tumour. (c). NCCT head on postoperative day1 shows a small infarct in left thalamus and a thin rim of extra axial collection in left frontotemporal convexity. (d). NCCT head on post operative day 10 showed subacute infarct in left thalamus and normal parenchyma in right cerebral hemisphere. (e). NCCT head on post op day 14 showed a massive right MCA infarct with significant midline shift. (f). NCCT head post decompression

Click here to view


The patient was conscious in the immediate postoperative period. On the first postoperative day the patient developed aphasia and right hemiplegia. Urgent CT scan showed a small infarct in the left thalamus. [Figure 1]c. There was no blood in the operated area or in the subarachnoid space. The speech and right hemiplegia improved over a few days with conservative management.

By postoperative day 4, patient developed polyuria and dyselectrolytemia. Endocrinology consultation was taken and diabetes insipidus was confirmed. The patient was started on injection vasopressin. He had wide fluctuation in serum sodium and fluid levels (serum sodium ranging from 125 to 165 meq/L, daily urine output ranging from 900 mL to 5800 mL) over the next two months) in spite of strict monitoring. Repeat NCCT head on postop day 10 revealed subacute infarct in left thalamus [Figure 1]d.

On postoperative day 12, the patient developed left focal seizures with secondary generalization which evolved into status epilepticus. Patient was managed with multiple antiepileptic drugs (fosphenytoin 100 mg twice daily, valproate 300 mg thrice daily, levetiracetam 400 mg twice daily, midazolam infusion, thiopentone infusion) with mechanical ventilation. Active convulsions had subsided, but EEG showed continuous epileptiform discharges suggestive of non-convulsive status epilepticus. Due to hemodynamic instability and recurrent seizures patient could not be shifted for brain imaging for the first 48 hours after seizure. On postoperative day 14, NCCT head could be done which revealed a large right middle cerebral artery (MCA) infarct with midline shift [Figure 1]e. CT angiogram could not be done. Urgent decompressive hemicraniectomy was performed [Figure 1]f. Over the next few days the anesthetic agents were gradually tapered with EEG monitoring. However, the patient remained comatose. He could not be weaned off the ventilator and succumbed four months after the surgery.


 » Discussion Top


Postoperative management of craniopharyngioma is often turbulent and fraught with many complications like fluid and electrolyte imbalance, seizures, infection, vascular complications etc., According to a previous review by Suero Molina et al.[1] 34 cases of documented cerebral vasospasm following trans sphenoidal surgery have been reported from 1980 till November 2018. After that two more cases of delayed cerebral vasospasm following pituitary surgery have been reported till November 2019.[2.3] Delayed cerebral vasospasm presenting as hemiparesis, altered sensorium, vision loss has been previously described.[1],[3],[4],[5],[6] One previous case report by Kasliwal et al. describes the onset of delayed cerebral infarction causing hemiparesis with focal seizures.[7] To the best of our knowledge, delayed cerebral infarction following vasospasm manifesting as status epilepticus has not been reported.

Our patient suffered from two ischemic events. The initial thalamic infarct could be due to perforator injury during surgery. The second right MCA infarct was possibly due to spasm of right MCA artery. The second stroke was clinically missed during the window period due to multiple confounders. The patient had more than one causes for decreased sensorium viz. dyselectrolytemia, status epilepticus, antiepileptic drugs, anesthetic agents and the stroke itself.

A previous review of literature by Alotaibi et al.[8] found 40 cases of cerebral vasospam following tumor resection. They concluded that pituitary tumours and surgery involving sellar area were most commonly associated with cerebral vasospasm. The cause of vasospasm has been ascribed to sub-arachnoid hemorrhage in the basal cisterns[9] mechanical trauma to vessels during surgery,[10] spillage of craniopharyngioma fluid[11] and hypothalamic involvement.[5] In our patient the last two factors were present. Also, there was fluid and electrolyte imbalance which must have aggravated the ischemia. The second stroke along with dyselectrolytemia was the likely cause of seizures which evolved into status epilepticus.

The unfortunate outcome could have been prevented by an earlier suspicion of cerebral infarction followed by imaging including angiography. This could have led to a timely diagnosis followed by intravascular intervention viz. intra-arterial papaverine[12] or milrinone[13] or balloon angioplasty. This was not possible in our patient since the imaging was delayed due to hemodynamic instability.


 » Conclusion Top


Postoperative management of craniopharyngioma is crucial and one should be vigilant for complications like endocrine insufficiency, fluid and electrolyte imbalance, seizures and ischemic events. Delayed cerebral infarction may present as hemiparesis, dip in sensorium, seizures or any new neurological deficit. Symptoms of new stroke may be missed in patients who are deeply comatose. There should be a high index of suspicion for delayed cerebral infarction in such cases with a low threshold for repeat brain imaging.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent from legally authorized representative for his patient's images and other clinical information to be reported in the journal.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
 » References Top

1.
Suero Molina E, Di Somma A, Stummer W, Briganti F, Cavallo LM. Clinical vasospasm after an extended endoscopic endonasal approach for recurrent pituitary adenoma: Illustrative case and systematic review of the literature. World Neurosurg 2019;128:29-36.  Back to cited text no. 1
    
2.
Aggarwal V, Nair P, Shivhare P, Kumar KS, Jayadevan ER, Nair S. Management of postoperative vasospasm following endoscopic endonasal surgery for craniopharyngioma: Report and review of literature. Neurol India 2019;67:606-9.  Back to cited text no. 2
[PUBMED]  [Full text]  
3.
Chhabra R, Singh A, Salunke P, Virk R. Unusual presentation of vasospasm masking underlying pseudoaneurysm after endoscopic transsphenoidal surgery in pituitary macroadenoma. World Neurosurg 2019;131:163-5.  Back to cited text no. 3
    
4.
Singh A, Salunke P, Rangan V, Ahuja CK, Bhadada S. Vasospasm after craniopharyngioma surgery: Can we prevent it? World Neurosurg 2017;101:208-15.  Back to cited text no. 4
    
5.
Kasliwal MK, Srivastava R, Sinha S, Kale SS, Sharma BS. Vasospasm after transsphenoidal pituitary surgery: A case report and review of the literature. Neurol India 2008;56:81.  Back to cited text no. 5
[PUBMED]  [Full text]  
6.
Salunke P, Sodhi HBS, Aggarwal A, Ahuja CK. Delayed cerebral vasospasm following surgery for craniopharyngioma. J Neurosci Rural Pract 2013;4:107-9.  Back to cited text no. 6
[PUBMED]  [Full text]  
7.
Alotaibi NM, Lanzino G. Cerebral vasospasm following tumor resection. J NeuroInterventional Surg 2013;5:413.  Back to cited text no. 7
    
8.
Ricarte IF, Funchal BF, Miranda Alves MA, Gomes DL, Valiente RA, Carvalho FA, et al. Symptomatic cerebral vasospasm and delayed cerebral ischemia following transsphenoidal resection of a craniopharyngioma. J Stroke Cerebrovasc Dis Off J Natl Stroke Assoc 2015;24:e271-3.  Back to cited text no. 8
    
9.
Macdonald RL, Hoffman HJ. Subarachnoid hemorrhage and vasospasm following removal of craniopharyngioma. J Clin Neurosci Off J Neurosurg Soc Australas 1997;4:348-52.  Back to cited text no. 9
    
10.
Chang SD, Yap OW, Adler JR. Symptomatic vasospasm after resection of a suprasellar pilocytic astrocytoma: Case report and possible pathogenesis. Surg Neurol 1999;51:521-6; discussion 526-7.  Back to cited text no. 10
    
11.
Shida N, Nakasato N, Mizoi K, Kanaki M, Yoshimoto T. Symptomatic vessel narrowing caused by spontaneous rupture of craniopharyngioma cyst--case report. Neurol Med Chir (Tokyo) 1998;38:666-8.  Back to cited text no. 11
    
12.
Clouston JE, Numaguchi Y, Zoarski GH, Aldrich EF, Simard JM, Zitnay KM. Intraarterial papaverine infusion for cerebral vasospasm after subarachnoid hemorrhage. AJNR Am J Neuroradiol 1995;16:27-38.  Back to cited text no. 12
    
13.
Yoshida K, Watanabe H, Nakamura S. Intraarterial injection of amrinone for vasospasm induced by subarachnoid hemorrhage. AJNR Am J Neuroradiol 1997;18:492-6.  Back to cited text no. 13
    


    Figures

  [Figure 1]



 

Top
Print this article  Email this article
   
Online since 20th March '04
Published by Wolters Kluwer - Medknow