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Year : 2020  |  Volume : 68  |  Issue : 4  |  Page : 927--929

A Complete and State of the Art Pre-mortem Diagnostic Approach to Creutzfeldt-Jakob Disease: A Case Report

1 Centro Especializado en Neurocirugía y Neurociencias México (CENNM), Mexico City, Mexico
2 Departamento de Anatomía, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico

Correspondence Address:
Dr. Parmenides Guadarrama-Ortiz
Centro Especializado en Neurocirugia y Neurociencias Mexico, Manzanillo and Tlaxcala 94, Roma Sur 06760, Mexico City
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.293483

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Sporadic Creutzfeldt-Jakob disease (sCJD) is a fatal and rapidly progressive form of dementia caused by the spread of a prion protein within the brain. Its real incidence is unknown since its definitive diagnosis requires histopathological analysis of brain specimens. However, novel tests that detect prion proteins in cerebrospinal fluid samples, such as the real-time quaking-induced conversion (RT-QuIC) technique, now allow the pre-mortem diagnosis of sCJD. Here, we report the first case of sCJD confirmed by RT-QuIC in Latin America, providing evidence of its diagnostic performance and clinical correlation.


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Online since 20th March '04
Published by Wolters Kluwer - Medknow