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Year : 2020  |  Volume : 68  |  Issue : 4  |  Page : 760--768

Clinicogenetical Variants of Progressive External Ophthalmoplegia - An Especial Review of Non-ophthalmic Manifestations


1 Department of Neurology, Zanjan University of Medical Sciences, Vali-e-Asr Hospital, Zanjan, Iran
2 Department of Neurology, Tehran University of Medical Sciences, Iranian Center of Neurological Research, Tehran, Iran

Correspondence Address:
Dr. Mehdi Maghbooli
Department of Neurology, Zanjan University of Medical Sciences, Vali-e-Asr Hospital, Zanjan
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.293454

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Progressive external ophthalmoplegia (PEO) is a slowly progressive myopathy characterized by extraocular muscles involvement, leading to frozen eyes without diplopia. The pattern of inheritance may be mitochondrial, autosomal dominant or, rarely, autosomal recessive. Sporadic forms were also reported. Muscular involvement other than extraocular muscles may occur with varying degrees of weakness, but this mostly happens many years after the disease begins. There are also scattered data about systemic signs besides ophthalmoplegia. This article aims to review non-ophthalmic findings of PEO from a clinicogenetical point of view.






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Online since 20th March '04
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