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Year : 2020  |  Volume : 68  |  Issue : 2  |  Page : 389--393

Application Value of 3.0-T Multivoxel 1H-MR Spectroscopy in the Peritumoral Tissue of Brain Astrocytic Tumors

1 Department of Radiology, Longyan First Hospital, Fujian Medical University, Longyan, Fujian, China
2 Department of Neurosurgery, Longyan First Hospital, Fujian Medical University, Longyan, Fujian, China

Correspondence Address:
Dr. Qi Lin
Department of Radiology, Longyan First Hospital, Fujian Medical University, No. 105 North 91 Road, Xinluo District, Longyan, 364000, Fujian
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.280633

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Objective: This study aimed to explore metabolic features in the peritumoral tissue of different-rank brain astrocytic tumors using multivoxel proton magnetic resonance spectroscopy (1H-MRS) and to estimate its application value in the MRS quantitative ratio of brain astrocytic tumors. Materials and Methods: A total of 82 patients with brain astrocytic tumors, confirmed by postoperative pathological evaluation, were divided into low-grade astrocytic tumors [World Health Organization (WHO) grade I–II; 32 cases] and high-grade astrocytic tumors (WHO grade III–IV; 50 cases). The semi-quantitative and relative quantitative metabolite ratios of the parenchyma area, peritumoral tissue area, and normal area were measured. The P value was set as <0.05. Results: The relative quantitative ratios of choline (Cho)/creatine (Cr) and Cho/N-acetyl aspartate (NAA) significantly differed in the peritumoral tissues of the high-grade astrocytic tumors and low-grade astrocytic tumors (P < 0.05), but NAA/Cr showed no significant difference. Conclusions: The changes in the metabolite ratio of the peritumoral tissue area in brain astrocytic tumors reflect the biological behavior of different tumors. They have a significant clinical value in classifying brain astrocytic tumors and indicating the scope of invasion.


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