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| NI FEATURE: PATHOLOGICAL PANORAMA - ORIGINAL ARTICLE |
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| Year : 2017 | Volume
: 65
| Issue : 1 | Page : 113--120 |
Histological spectrum of oligodendroglial tumors: Only a subset shows 1p/19q codeletion
Trupti Pai1, Sridhar Epari2, Sangeeta Desai3, Amol Wadile2, Tejpal Gupta4, Jayant S Goda4, Aliasgar Moiyadi5, Prakash Shetty5, Shubhada Kane2, Rakesh Jalali4
1 Division of Molecular Pathology, Tata Memorial Centre, Mumbai, Maharashtra, India
2 Department of Pathology, Tata Memorial Centre, Mumbai, Maharashtra, India
3 Division of Molecular Pathology, Tata Memorial Centre, Mumbai, Maharashtra; Department of Pathology, Tata Memorial Centre, Mumbai, Maharashtra, India
4 Department of Radiation Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India
5 Department of Neurosurgery, Tata Memorial Centre, Mumbai, Maharashtra, India
Correspondence Address:
Sridhar Epari
Department of Pathology, 8th Floor, Annexe building, Tata Memorial Centre, Mumbai - 400 012, Maharashtra
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0028-3886.198195
Background: Canonical oligodendroglial tumors (ODGs) are characterized genetically by chromosomes 1p/19q codeletion.
Aims: This study was essentially aimed at the detection of frequency of 1p/19q codeletion in the different histological spectrum of ODG tumors in a large cohort of Indian patients.
Materials and Methods: All the ODG tumors evaluated for 1p/19q by fluorescence in-situ hybridization (FISH) during 2009–2015 were correlated with histology, immunohistochemical expression for p53 protein and clinical features.
Results: A total of 676 cases included both pediatric (n = 18) and adult (n = 658) patients. Histologically, 346 pure ODGs [oligodendroglioma (OD) and anaplastic oligodendroglioma (AOD)] and 330 mixed ODGs [oligoastrocytomas (OA), anaplastic oligoastrocytomas (AOA) and glioblastoma with oligodendroglioma component (GBM-O)] were included. 1p/19q co-deletion was noted in 69% (60/87), 55.9% (145/259), 18.2% (18/99), 10.5% (18/172), and in 5.1% (3/59) cases of OD, AOD, OA, AOA, and GBM-O, respectively. In the pediatric age-group, 1p/19q codeletion was seen in 25% (2/8) of pure ODGs and in 10% (1/10) of mixed ODGs. In adults, it was observed in 60% (203/338) cases of pure ODGs and in 11.9% (38/320) cases of mixed ODGs. In adults, pure ODG histology (P = 0.00), frontal location (P = 0.004), calcification [in pure ODGs] (P = 0.03), and lack of p53 protein overexpression (P = 0.00) showed significant statistical correlation with 1p/19q codeletion.
Conclusions: This study is unique in being one of the largest on ODGs for 1p/19q co-deletion including both pediatric and adult age groups of Indian patients. The results showed co-deletion in 60% of adult ODGs and 25% of pediatric pure ODGs. This reemphasizes the occurrence of 1p/19q codeletion, even though rare, in the pediatric age group.
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