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Year : 2016  |  Volume : 64  |  Issue : 1  |  Page : 56--61

Rheumatoid arthritis and the risk of dementia: A systematic review and meta-analysis

1 Department of Internal Medicine, Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA; Department of Medicine, Division of Rheumatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
2 Department of Medicine, Bassett Medical Center, Cooperstown, New York, USA

Correspondence Address:
Patompong Ungprasert
Division of Rheumatology, Mayo Clinic, 200 First street SW, Rochester - 55905, Minnesota, USA

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.173623

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Background: The association between chronic inflammation and dementia has been identified in several epidemiologic studies. However, the data on rheumatoid arthritis (RA), one of the most common chronic inflammatory disorders, remains unclear. Materials and Methods: We conducted a systematic review and meta-analysis of cohort, case–control, and cross-sectional studies that compared the risk of dementia in patients with RA versus non-RA controls. Data from each study were combined using random-effect, generic inverse variance method of DerSimonian and Laird to calculate the pooled risk ratio (RR) and 95% confidence interval (CI). Results: Three cohort studies and two cross-sectional studies were identified and included in the meta-analysis. We found a significantly increased risk of dementia among patients with RA, with the pooled risk ratio of 1.61 (95% CI, 1.10–2.37). The statistical heterogeneity was high, with an I2 of 91%. Conclusions: Our study demonstrated a statistically significant increase in the risk of dementia among patients with RA.


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Online since 20th March '04
Published by Wolters Kluwer - Medknow