| ORIGINAL ARTICLE |
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| Year : 2011 | Volume
: 59
| Issue : 4 | Page : 521--526 |
Association of atherosclerotic cerebral infarction and human leukocyte antigen-DRB in a North Chinese Han population
Song-Yan Liu1, Ying Chang1, Shuang-Yan Zhang2, Wei Wu3, Bo-Jian Sun4, Xue-Mei Han1
1 Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun, Jilin, China
2 The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China
3 Department of Neurosurgery, The First Hospital, Jilin University, Changchun, Jilin, China
4 Class of 2014, Bates College, Lewiston, ME, USA
Correspondence Address:
Xue-Mei Han
Department of Neurology, China-Japan Union Hospital, Jilin University, 126 Xiantai Street, Changchun, Jilin 130033
China
 Source of Support: Jilin Provincial Science & Technology Department (200505169), Conflict of Interest: None  | Check |
DOI: 10.4103/0028-3886.84330
Background and Objectives: Evidence from experimental and genetic studies suggest the existence of a potential link between the polymorphisms of human leukocyte antigen class II gene (HLA-DR) and ischemic stroke. This study addressed the association of HLA-DR gene with atherosclerotic cerebral infarction (ACI) in a North Chinese Han population. Material and Methods: The genotyping of HLA-DRB1 was determined by standard techniques based on polymerase chain reaction and sequence-specific oligonucleotides hybridization in a gene chip. Results: The relative risk (RR) of HLA-DRB1 * 04 and HLA-DRB1 * 03 (17) in patients with ACI and their first-degree relatives were significantly higher than those in the control group (RR=2.56 and 18.77, respectively; P <0.05). In contrast, the RR of HLA-DRB1 * 12 was dramatically reduced in patients with ACI in relation to healthy controls (RR=0.17; P <0.01). Conclusions: These data indicate that the polymorphisms in HLA-DRB1 may influence the risk of ACI in the North Han population of China. Further studies are necessary to validate the observation in larger samples.
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