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Year : 2010  |  Volume : 58  |  Issue : 4  |  Page : 560--564

Comparison of 1 week versus 4 weeks of albendazole therapy in single small enhancing computed tomography lesion

1 Department of Pediatrics, Government Multi Speciality Hospital, Sector 16, Chandigarh- 160 015, India
2 Department of Radiology, Government Multi Speciality Hospital, Sector 16, Chandigarh- 160 015, India

Correspondence Address:
Neeraj Dhawan
H. No. 6144, MHC, Manimajra, Chandigarh- 160 101
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.68677

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Background : The appropriate duration of albendazole therapy in neurocysticercosis is uncertain. The observation in small uncontrolled randomized trials in children that short-course therapy (1 week) is as effective as the conventional regimen (4weeks) must be tested. Objective : To compare the efficacy of 1 and 4 weeks of albendazole therapy in children with single small enhancing computed tomographic lesion (SSECTL). Study Design: An open-labeled, randomized, clinical trial. Materials and Methods : One hundred twenty children with SSECTLs presenting with seizure. Intervention: The subjects were assigned to two groups using random tables: group A (n=58) received albendazole for 1 week and group B (n=62) for 4 weeks. All the subjects were followed up for 6 months. Results : The proportions of subjects with complete resolution of lesion in the two groups were similar (group A 63.8% versus group B 51.6%). The proportion of subjects in the two groups in whom the lesion calcified on follow up (group A 19% versus group B 24.2%) also did not differ significantly. The incidence of seizure recurrence during the 6-month follow-up period was also similar in both the groups (group A 9.6% versus group B 3.4%, P > 0.05). Conclusion : One week of albendazole therapy is as effective as 4 weeks of therapy in children with SSECTLs.


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Online since 20th March '04
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