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Year : 2010  |  Volume : 58  |  Issue : 4  |  Page : 530--536

Protective effects of the calcium-channel blocker flunarizine on crush injury of sciatic nerves in a rat model

1 Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing- 210 029, China
2 Department of Pathology, Changzhou Tumor Hospital, Changzhou- 213005, China
3 Department of Neurotoxicology, Nanjing Medical University, Nanjing- 210029, China
4 Department of Pathology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing- 210018, China
5 Department of Statistics, Nanjing Medical University, Nanjing- 210029, China

Correspondence Address:
Jin-Rong Tang
Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing - 210 029
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Source of Support: Medical Research Council, Conflict of, Conflict of Interest: None

DOI: 10.4103/0028-3886.68665

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Background : Neural damage can be mitigated by calcium-channel blockers (CCBs). However, the mechanism of action of CCBs is not yet fully understood. Objective : To investigate the mechanism of action and efficacy of CCB, flunarizine in restoring neural function after crush injury to the nerves Materials and Methods : The sciatic nerves of rats were crushed using pincers to establish the model for crush injury. Two hundred and eighty-eight Sprague-Dawley (SD) rats were randomly divided into sham-operated, saline, and low-dose flunarizine and high-dose flunarizine (FI and FII) groups. The expression of the protein c-fos in the dorsal root ganglia (DRG) after crush injury to the sciatic nerves was investigated by using reverse transcription-polymerase chain reaction (RT-PCR) and Western blot. The effect of flunarizine on c-fos expression and its efficacy in restoring neural function was evaluated. Results : The c-fos messenger ribonucleic acid (mRNA) and protein expression in FI and FII groups was significantly lower than in the saline group and was the least in the FII group. Nerve-conduction velocity was increased in the order of: saline < FI< FII< sham-operated. There was no significant difference in the nerve-conduction velocity in the sham-operated and FII groups (P>.05). Conclusions : When administered after crush injury to peripheral nerves, flunarizine may protect neurons with lesions from further damage and improve neural function by downregulating c-fos expression.


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Online since 20th March '04
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