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 CASE REPORT
Year : 2010  |  Volume : 58  |  Issue : 3  |  Page : 449--451

Glutamic acid decarboxylase antibody-positive paraneoplastic stiff limb syndrome associated with carcinoma of the breast


1 Department of Neurology, Aditya Birla Memorial Hospital, Pune, Maharashtra, India
2 Department of Neurology, Jehangir Hospital and Research Center, Pune, Maharashtra, India

Correspondence Address:
Pankaj A Agarwal
Department of Neurology, Aditya Birla Memorial Hospital, Chinchwad, Pune - 411 033
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.65704

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Stiff limb syndrome (SLS) is a rare "focal" variant of stiff person syndrome which presents with rigidity and painful spasms of a distal limb, and abnormal fixed foot or hand postures. Anti-glutamic acid decarboxylase antibodies (GAD-Ab) are variably present in most cases. Most reported cases of SLS are unassociated with cancer. We describe a patient with SLS as a paraneoplastic manifestation of breast carcinoma, in whom GAD-Ab was present. The patient responded very well to oral diazepam, baclofen and steroids.This is the third reported case of SLS as a paraneoplastic accompaniment to cancer.






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Online since 20th March '04
Published by Wolters Kluwer - Medknow