| ORIGINAL ARTICLE |
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| Year : 2010 | Volume
: 58
| Issue : 1 | Page : 53--57 |
Parkinson's disease: Functional changes in frontal and parietal cortex using 18 F- fluoro-deoxy glucose positron emission tomography/computed tomography
Zhongyu Hou1, Shuhui Hong2, Bo Sun3, Xiangtao Lin3, Qingwei Liu4, Shuzhan Yao4, Shuwei Liu3
1 Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, Jinan; Department of Radiology, Provincial Hospital Affiliated to Shandong University, Jinan, China
2 Qianfoshan Hospital Affiliated to Shandong University, Jinan, China
3 Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, Jinan, China
4 Department of Radiology, Provincial Hospital Affiliated to Shandong University, Jinan, China
Correspondence Address:
Shuwei Liu
Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, 44 Wenhua Xi Road, Jinan - 250 012
China
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0028-3886.60397
Background : In Parkinson's disease (PD) there is increasing evidence to suggest motor function changes of the cerebral cortex occur in addition to the pathological changes in the extrapyramidal system. Aims : To explore the functional changes in the frontal and parietal cortex in PD cat model. Settings and Design : Twenty-four healthy male cats were divided into four animal model groups with the injection of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), and one control group. Materials and Methods : Cats in both the animal model and control groups were observed for the behavioral changes. They were also examined by 18 F-fluoro-deoxy glucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT). Region of Interest (ROI) was determined by 18 F-FDG intensity and semi-quantitative analysis was employed after detecting the standard absorption value (SUV). Statistical Analysis : Statistical significance was evaluated by ANOVA. Results : Compared to control group, the 18 F-FDG intensity and SUV were found normal on both the sides of frontal and parietal cortex in the PD models on the second day (P > 0.05), and on the fifth day, they were reduced significantly on both the sides of frontal cortex exclusively (P < 0.05). Moreover on the eighth day, the SUV of both frontal cortexes was reduced, while it was increased in both parietal cortex (P < 0.05). Finally on the eleventh day, the SUV remained stable in both the frontal cortex, and was back to normal level in both the parietal cortex. Conclusions : Functional disorders exist in the frontal cortex of PD animals and aggravate with time. Transient functional enhancement in the parietal cortex of PD cats might be a compensation for the dysfunction of frontal cortex.
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