| Article Access Statistics | | | Viewed | 2570 | | | Printed | 153 | | | Emailed | 0 | | | PDF Downloaded | 92 | | | Comments | [Add] | | | Cited by others | 3 | | |
|
Click on image for details.
|
|
| LETTER TO EDITOR |
|
|
|
| Year : 2010 | Volume
: 58
| Issue : 1 | Page : 160-162 |
Melanotic craniopharyngioma, an unusual variant in a young female
Nandita Ghosal1, Ravi Dadlani2, Sai Kiran2, AS Hegde3
1 Department of Pathology and Transfusion Medicine, SSSIHMS, Bangalore, India
2 Department of Neurosurgery, SSSIHMS, Bangalore, India
3 Department of Neurosciences, SSSIHMS, India
| Date of Acceptance | 02-Nov-2009 |
| Date of Web Publication | 8-Mar-2010 |
Correspondence Address:
Nandita Ghosal
Department of Pathology and Transfusion Medicine, SSSIHMS, Bangalore
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0028-3886.60433
How to cite this article:
Ghosal N, Dadlani R, Kiran S, Hegde A S. Melanotic craniopharyngioma, an unusual variant in a young female. Neurol India 2010;58:160-2 |
Sir,
A 33-year-old female presented with a history of amenorrhea for the last seven years, headache of one year and diminution of vision since the last six months. There were no seizures or symptoms of endocrine dysfunction. The diminution of vision was more in the left eye. The magnetic resonance imaging (MRI) showed a sellar, suprasellar lesion with a cystic component measuring 4.7 x 2.8 x 4.2 cm extending up to the anterior part of the third ventricle [Figure 1]a. A pterional craniotomy and decompression of the tumor was done. The sample was sent to an outside hospital for evaluation and a histopathological diagnosis of an adamantinomatous craniopharyngioma was given without mention of any melanin pigment. The patient presented after eight years with similar complaints. MRI this time revealed a well defined dumbbell shaped sellar, suprasellar mass lesion measuring 3.4 x 3 x 4.9 cm, predominantly cystic with contrast enhancing solid component [Figure 1]b, extending inferiorly into the sellar, superiorly into the third ventricle causing mild hydrocephalus and posteriorly into the interpeduncular cistern and left temporal lobe. Tumor decompression was done and an Ommaya chamber was placed in the residual cyst. The specimen was sent for histopathological evaluation to the Department of Pathology, Sri Sathya Sai Institute of Higher Medical Sciences. On light microscopy, the tumor was predominantly cystic lined by squamous cells resembling epidermoid cyst with a few foci showing odontogenic epithelium, squamous nests, dystrophic calcification and wet keratin [Figure 2]. There was subepithelial fibrosis with focal collections of chronic inflammatory cells including foamy macrophages. In addition, granular brown black pigment was seen near the wet keratin, between the inflammatory cells and inside a few squamous cells few tumor cells [Figure 3]a and b. The pigment was negative on Perl's iron stain [Figure 4]a. Following Schmorl's technique of melanin bleach, the pigment disappeared [Figure 4]b. On the basis of histomorphological features and special stains a diagnosis of melanotic craniopharyngioma, sellar, suprasellar region was given. Melanotic craniopharyngiomas are extremely rare. Review of literature revealed only three cases [Table 1]. [1],[2] In the melanotic craniopharyngioma it can be presumed that due to the embryologic similarity between the former and odontogenic tumors; the melanotic cells arose from cells analogous to the paradental epithelium. It is also proposed in literature that these tumors may possibly become pigmented by melanin transfer from leptomeningeal melanocytes or contain entrapped leptomeningeal melanocytes as described for some melanin harboring meningiomas. [3] It should be noted though that many of the neuroepithelial and glial tumors do rarely show presence of melanocytic differentiation. [4] It is very interesting to note that all the reported cases and the present case occurred in dark complexioned people.
As suggested by the previous authors, this fact of the race and skin color being one of the contributing factors in the development of this rare variant needs to be evaluated further. However, due to the rarity of this variant it is difficult to establish this fact at this juncture. To conclude, we report an extremely rare case of melanotic craniopharyngioma in a young female, which to the best of our knowledge is the fourth case in the literature.
| » References | |  |
| 1. | Harris BT, Horoupian DS, Victor T, Herrick MK. Melanotic craniopharyngioma: A report of two cases. Acta Neuropathol 1999;98:433-6.  |
| 2. | Panabokke RG, Ranasinha K, Kumaranayake CS. Craniopharyngioma pigmented with melanin. Ceylon Med J 1970;15:182-3. [PUBMED] |
| 3. | Brat DJ, Giannini C, Scheithauer BW, Burger PC. Primary melanocytic neoplasms of the central nervous system. Am J Surg Pathol 1999;23:745-54. [PUBMED] [FULLTEXT] |
| 4. | Krossnes BK, Mella O, Wester K, Mork SJ. Pigmented astrocytoma with suprasellar location: Case report and literature review. Acta Neuropathol (Berl) 2004;108:461-6. |
[Figure 1], [Figure 2], [Figure 3], [Figure 4]
[Table 1]
| This article has been cited by | | 1 |
Intracranial Neurenteric Cyst with an Enhanced Mural Nodule and Melanin Pigmentation: Radiologic-Pathologic Correlation |
|
| Junkoh Yamamoto,Shohei Shimajiri,Daisuke Akiba,Yoshiteru Nakano,Shigeru Nishizawa | | World Neurosurgery. 2017; 97: 758.e11 | | [Pubmed] | [DOI] | | | 2 |
Calvarial malignant melanotic neuroectodermal tumour of infancy presenting with widespread intracranial metastasis |
|
| Furtado, S.V. and Ghosal, N. and Hegde, A.S. | | Journal of Cranio-Maxillofacial Surgery. 2012; 40(6): e170-e173 | | [Pubmed] | | | 3 |
Calvarial malignant melanotic neuroectodermal tumour of infancy presenting with widespread intracranial metastasis |
|
| Sunil V. Furtado,Nandita Ghosal,Alangar S. Hegde | | Journal of Cranio-Maxillofacial Surgery. 2012; 40(6): e170 | | [Pubmed] | [DOI] | |
|
|
|
|
