| BRIEF REPORT |
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| Year : 2009 | Volume
: 57
| Issue : 4 | Page : 460--463 |
Pyridoxine-dependent seizures: 10-year follow-up of eight cases
Roshan Koul
Department of Child Health, College of Medicine and Health Sciences, Sultan Qaboos University Hospital, Muscat, Oman
Correspondence Address:
Roshan Koul
Senior Consultant and Child Neurologist, SQUH. BW1,Muscat
Oman
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0028-3886.55595
Eight children with pyridoxine-dependent seizures (PDS) were seen over a period of 10 years. Of those children, 6 are on regular follow-up. Four of the children were seen in one family. All the patients presented with refractory seizures, mainly neonatal status epilepticus. Though PDS is a rare condition, it must be considered in all cases with refractory seizures, particularly in childrens younger than 3 years. When confirming a diagnosis, oral pyridoxine is as effective as intravenous pyridoxine.
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