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Year : 2008  |  Volume : 56  |  Issue : 3  |  Page : 363--367

Major histocompatibility complex class I expression can be used as a diagnostic tool to differentiate idiopathic inflammatory myopathies from dystrophies

1 Department of Pathology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, India
2 Department of Neurology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, India

Correspondence Address:
C Sundaram
Department of Pathology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad - 500 082
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.43457

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Aim: Utility of major histocompatibility complex (MHC) Class I antigen immunostaining was studied to differentiate idiopathic inflammatory myopathies from dystrophies. Materials and Methods: Forty muscle biopsies including seven dermatomyositis (DM), six polymyositis (PM), two sporadic inclusion body myositis (sIBM), 20 dystrophies (one Duchenne, three Becker's, four alpha, one gamma sarcoglycanopathy, nine limb girdle, one myotonic and one fascioscapulohumeral muscular dystrophy) and five controls were stained with antibody for MHC Class I antigen (Novocastra clone W6/32 HL 1:100 dilution). Results: Polymyositis and sIBM showed MHC class I antigen positivity along sarcolemma of single and small groups of muscle fibers. The regenerating fibers in the perifascicular area in DM showed intense cytoplasmic positivity of MHC class I antigen. Muscle fibers in all dystrophies except regenerating fibers and control normal muscle were negative for MHC. Capillaries and lymphocytes were positive controls. There were no false positives in the study. Conclusion: MHC Class I immunostaining can be used as a complementary diagnostic tool for the diagnosis of idiopathic inflammatory myopathies.


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Online since 20th March '04
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