Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 5688  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 »   Next article
 »   Previous article
 »   Table of Contents

 Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded387    
    Comments [Add]    
    Cited by others 12    

Recommend this journal


Year : 2007  |  Volume : 55  |  Issue : 2  |  Page : 122--129

The correlation of carotid plaque pathohistologic features and neurological symptoms: A meta-analysis of observational studies

1 Department of Neurosurgery, Tongji Hospital, Tongji University, 389 XinCun Road, Shanghai - 200065, China
2 Department of Neurosurgery, Xuanwu Hospital, Capital University of Medical Science, Beijing - 100053, China

Correspondence Address:
Feng Ling
389 XinCun Road, Shanghai 200065
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.32782

Rights and Permissions

Objective: To investigate the association between the pathological features of carotid plaque and ipsilateral symptoms of cerebral ischemia. Materials and Methods: We sought to identify clinical observational studies comparing the incidence of pathological features between symptomatic and asymptomatic carotid plaques in terms of ulceration, thrombosis and intraplaque hemorrhage (IPH), published between 1996 and 2006. A search on, PubMed was supplemented by a review of bibliographies of relevant articles and lists of references in it. Odds ratios (OR) for the presence of each feature as a role in the pathogenesis of neurological events were calculated and combined by a meta-analysis. Results: We integrated 16 clinical studies totaling 2839 plaques harvested at endarterectomy procedures. The reported incidence for each feature was highly variable. The methods in defining ulceration, thrombosis and IPH were very heterogeneous. The time intervals between the latest onset of ischemic symptoms and pathological examinations varied greatly. Overall, the incidence of ulcerated plaques in the symptomatic group were significantly higher than that in the asymptomatic group (study number, n=10; OR, 2.32; 95% CI, 1.90-2.83. A random-effect model was performed among studies regarding surface thrombosis because an apparent trend for heterogeneity was observed (n=6; OR, 1.57; 95% CI, 0.68-3.64). There was no difference with respect to IPH between the two groups (n=11; OR, 1.09; 95% CI, 0.91-1.32). Conclusions: Ulcerated carotid plaque is significantly correlated with the production of neurological events, whereas thrombosis fails to correlate with ischemic symptoms because of the presence of substantial heterogeneity. The association between IPH and clinical presentations is less clear.


Print this article     Email this article

Online since 20th March '04
Published by Wolters Kluwer - Medknow