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NEUROIMAGE
Year : 2006  |  Volume : 54  |  Issue : 3  |  Page : 327

Cortical laminar necrosis following anoxic encephalopathy


1 Department of Neurology, Saint Vincent's Hospital and Medical Centers, New York, USA
2 Department of Medicine, Saint Vincent's Hospital and Medical Centers, New York, USA

Date of Acceptance05-Aug-2006

Correspondence Address:
N K Sethi
Saint Vincent's Hospital and Medical Centers, 153 West, 11th Street, New York, NY 10011
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.27178

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How to cite this article:
Sethi N K, Torgovnick J, Macaluso C, Arsura E. Cortical laminar necrosis following anoxic encephalopathy. Neurol India 2006;54:327

How to cite this URL:
Sethi N K, Torgovnick J, Macaluso C, Arsura E. Cortical laminar necrosis following anoxic encephalopathy. Neurol India [serial online] 2006 [cited 2023 Jan 28];54:327. Available from: https://www.neurologyindia.com/text.asp?2006/54/3/327/27178


Neurology consultation was requested for status epilepticus on a 48-year-old male in the medical intensive care unit. Patient had been found unresponsive outside a bar by the emergency medical services. An empty bottle of bupropion was found on his person. Cardiopulmonary resuscitation had been initiated in the field and a peripheral pulse was detected after 10 min. Admission EtOH level was 175 mg/dL. On examination, the patient was unresponsive to verbal commands and decerebrated on deep painful stimuli. Deep tendon reflexes were brisk bilaterally and he had well sustained bilateral ankle clonus with bilateral upgoing plantars. Seizures were hard to control, requiring intravenous phenytoin and phenobarbital loading and finally intravenous midazolam. Cerebral MR done 10 days after presentation showed gyriform increased signal in both the temporal and parietal lobes, suggestive of cortical laminar necrosis [Figure - 1][Figure - 2].


 » Discussion Top


The gray matter of the cortex has six layers. The third layer is the most vulnerable to anoxia and hypoglycemia. Cortical laminar necrosis is a specific type of cortical infarction, usually seen in the setting of anoxic encephalopathy. Other etiologies like hypoglycemia, status epilepticus and immunosuppressive chemotherapy have been implicated.[1],[2] The appearance of the MR images in the setting of diffuse cortical laminar necrosis can be deceptive. Properly windowed diffusion weighted imaging can be very helpful in detecting cortical laminar necrosis, especially in the setting of anoxic-hypoxic encephalopathy in the early subacute phase.[3] Cortical laminar necrosis in the setting of anoxic encephalopathy has a universally poor prognosis, with most patients either progressing to brain death or remaining in a persistent vegetative state.[2] Our patient too had a poor outcome and remains in a persistent vegetative state.

 
 » References Top

1.Donaire A, Carreno M, Gomez B, Fossas P, Bargallo N, Agudo R, et al . Cortical laminar necrosis related to prolonged focal status epilepticus. J Neurol Neurosurg Psychiatr 2006;77:104-6.  Back to cited text no. 1    
2.Yoneda Y, Yamamoto S. Cerebral cortical laminar necrosis on diffusion-weighted MRI in hypoglycaemic encephalopathy. Diab Med 2005;22:1098-100.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]
3.McKinney AM, Teksam M, Felice R, Casey SO, Cranford R, Truwit CL, et al . Diffusion-weighted imaging in the setting of diffuse cortical laminar necrosis and hypoxic-ischemic encephalopathy. AJNR Am J Neuroradiol 2004;25:1659-65.  Back to cited text no. 3    


    Figures

[Figure - 1], [Figure - 2]

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