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| INVITED COMMENTS |
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| Year : 2005 | Volume
: 53
| Issue : 3 | Page : 302 |
Invited Comments
Gudrun Boysen
Dept. of Neurology, Bispebjerg Hospital, DK-2400 Copenhagen NV, USA
Correspondence Address:
Gudrun Boysen
Dept. of Neurology, Bispebjerg Hospital, DK-2400 Copenhagen NV
USA
 Source of Support: None, Conflict of Interest: None  | Check |
How to cite this article:
Boysen G. Invited Comments. Neurol India 2005;53:302 |
This study shows that hyperhomocysteinaemia is associated with an increased risk of stroke in India as has been shown in many other countries in the world. Elevated homocysteine is a risk factor for stroke both in the young[1] and in the elderly,[2] as well as for recurrent stroke.[3] Numerous studies have shown that supplementation with folate, vitamin B6, and B12 reduces the level of homocysteine. Intervention studies have so far been disappointing in being unable to show a reduced risk of stroke and cardiovascular events in vitamin B-treated groups,[4],[5] however, the results of many ongoing randomized trials are awaited with great expectations.[6] In the meantime, however, it is tempting to recommend vitamin supplementation for patients with highly elevated homocysteine levels.
| » References | |  |
| 1. | Bos MJ, van Goor ML, Koudstaal PJ, Dippel DW. Plasma homocysteine is a risk factor for recurrent vascular events in young patients with an ischemic stroke or TIA. J Neurol 2005;152:332-7.  |
| 2. | Iso H, Moriyama Y, Sato S, Kitamura A, Tanigawa T, Yamagishi K, et al. Serum total homocysteine concentrations and risk of stroke and its subtypes in Japanese. Circulation 2004;109:2766-72. [PUBMED] [FULLTEXT] |
| 3. | Boysen G, Brander T, Christensen H, Gideon R, Truelsen T. Homocysteine and risk of recurrent stroke. Stroke 2003;34:1258-61. [PUBMED] [FULLTEXT] |
| 4. | Toole JE, Malinow MR, Chambless LE, Spence JD, Howard VJ, Sides EG, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death. JAMA 2004;291:565-75. |
| 5. | Lange H, Suryapranata H, De Luca G, Borner C, Dille J, Kallmayer K, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81 [PUBMED] [FULLTEXT] |
| 6. | Clarke R. Homocysteine-lowering trials for prevention of heart disease and stroke. Semin Vasc Med 2005;5:215-22. [PUBMED] |
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