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LETTER TO EDITOR
Year : 2003  |  Volume : 51  |  Issue : 2  |  Page : 283

Authors’ Reply


Department of Neurology, NIMS, Punjagutta, Hyderabad.

Correspondence Address:
Department of Neurology, NIMS, Punjagutta, Hyderabad.
[email protected]



How to cite this article:
Jayalakshmi S S, Borgohain R, Mohandas S. Authors’ Reply . Neurol India 2003;51:283


How to cite this URL:
Jayalakshmi S S, Borgohain R, Mohandas S. Authors’ Reply . Neurol India [serial online] 2003 [cited 2023 Jan 29];51:283. Available from: https://www.neurologyindia.com/text.asp?2003/51/2/283/1113


Sir,
We would like to reply to the three points raised as follows. 1. Our patient with recurrent Miller-Fisher syndrome (MFS) had no antecedent illness during the second episode as mentioned in the case report.[1] Antecedent infection is not always present and it has been found in 60-80% of patients with Guillian Barre syndrome and those with anti-GQ1b IgG antibody syndrome.[2],[3] 2. Though it has been found that serum anti GQ1b Ig G antibodies is associated with MFS, antiGQib IgG antibodies may not be uniformly present as mentioned. 3. It has been mentioned in the letter that “their silence as to the possible relationship between this family of syndromes and multiple sclerosis, remembering that remission and exacerbation is the hallmark of the latter condition”. Our patient had definite neuropathy as evidenced by the prolonged F wave responses, reduced motor conduction velocities and absent sensory nerve action potentials in the upper and lower limbs. The nerve biopsy showed segmental demyelination. Hence the possibility of multiple sclerosis cannot be considered.
 

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1.Sitajayalakshmi S, Borgohain R, Mani J, Mohandas S. Recurrent Miller Fisher syndrome: a case report. Neurol India 2002;50:365-7.  Back to cited text no. 1  [PUBMED]  [FULLTEXT]
2.Caudie C, Vial C, Bancel J, Petiot P, Antoine JC, Gonnaud PM. Antiganglioside autoantibody profiles in Guillain-Barre syndrome. Ann Biol Clin (Paris) 2002; 60:589-97.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]
3.Odaka M, Yuki N, Hirata K. Anti-GQ1b IgG antibody syndrome: clinical and immunological range. J Neurol Neurosurg Psychiatry. 2001;70:50-5.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]

 

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Online since 20th March '04
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