| SHORT REPORTS |
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| Year : 2003 | Volume
: 51
| Issue : 2 | Page : 277--279 |
The significance of corpora amylacea in mesial temporal lobe epilepsy
P Joseph Cherian, V Radhakrishnan, K Radhakrishnan
R. Madhavan Nayar Center for Comprehensive Epilepsy Care and Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695011, India
Correspondence Address:
K Radhakrishnan
Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695011.
India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 14571029 
Temporal lobe epilepsy (TLE) associated with mesial temporal sclerosis (MTS), mesial TLE (MTLE), is the commonest medically refractory adult epilepsy syndrome. Corpora amylacea (CoA) have been shown to be a marker of MTS. We compared 9 patients with MTS who had dense deposition of CoA in their hippocampi with 25 patients with MTS who did not have CoA. The patients with CoA were significantly older and they showed a trend towards having a significantly longer duration of epilepsy. The postoperative seizure outcome at 2 years was not different in the 2 groups. Our results could indicate the progressive nature of the pathology of MTS, probably indicating excitotoxic damage due to recurrent seizures, but they need to be verified by clinicopathological correlation among a larger number of patients with MTLE.
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