| ORIGINAL ARTICLE |
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| Year : 2003 | Volume
: 51
| Issue : 2 | Page : 208--210 |
Nadroparin plus aspirin versus aspirin alone in the treatment of acute ischemic stroke
GR Sarma, AK Roy
Department of Neurology, St.John’s Medical College Hospital, Bangalore, India
Correspondence Address:
G R Sarma
Department of Neurology, St. John’s Medical College Hospital, Bangalore
India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 14571005 
Low-molecular-weight-heparin (LMWH) has been widely used in the treatment of acute ischemic stroke but controlled trials are few. In this study, 40 patients with acute ischemic stroke of less than 24 hours duration were randomized to receive either aspirin (325 mg/day) alone or aspirin (325 mg/day) plus subcutaneous nadroparin 4100 units/day. At the end of 4 weeks, the morbidity and mortality were significantly less in the nadroparin group as compared to the aspirin group. There was no increased risk of clinically significant intracranial hemorrhage in either group. The combination of aspirin and LMWH deserves to be tested in larger studies.
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