|Year : 1998 | Volume
| Issue : 3 | Page : 229--231
Influence of kinnow juice on the bioavailability of carbamazepine in healthy male volunteers.
SK Garg, VK Bhargava, H James, N KuJan-Mar, S Prabhakar, KuJan-Mar Naresh
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012, India
Kinnow juice produces a marked and variable increase in carbamazepine bioavailability. The pharmacokinetics of carbamazepine was studied after drug administration with 300 ml water or kinnow juice in a randomized cross over trial on nine healthy male volunteers. With kinnow juice peak serum concentration (Cmax) and area under the serum concentration time curve (AUC) was significantly (P < 0.05) increased and time to reach peak serum concentration (tmax) was significantly decreased (p < 0.05) as compared with water. No change was observed in the elimination half life (t1/2) of drug. The mechanism by which kinnow juice enhances carbamazepine bioavailability could be due to inhibition of cytochrome P-450 enzyme, since kinnow juice contains naringin which is considered to be inhibitor of liver microsomal dihydropyridine oxidation.
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012
Source of Support: None, Conflict of Interest: None
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