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Year : 1998  |  Volume : 46  |  Issue : 2  |  Page : 102--104

Gabapentin in refractory partial seizures.


Department of Neurology, Govt. General Hospital, Madras - 600 003, India

Correspondence Address:
M Dhanaraj
Department of Neurology, Govt. General Hospital, Madras - 600 003
India
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Source of Support: None, Conflict of Interest: None


PMID: 29508795

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We report our preliminary observations on the role of Gabapentin as an add - on therapy in 16 patients with partial or secondary generalised seizures who were resistant to conventional antiepileptic drugs. There was a reduction in the seizure frequency by more than 50 in 11 (69), less than 50 in 3 (18.75), and increase in 1 (6.25). Adverse effects were noted in 9 (56.25 ) of them. The giddiness and sleepiness was seen in 5 (31.25 ); in one it was so severe that he withdrew from the study. Ataxic gait was observed in 1 (6.25). Reduction in the haemoglobin by 2 gms. occurred in 2 (12.5) and asymptomatic eosinophilia in 1 (6.25). As an add - on drug, the efficacy of Gabapentin was good. Regular haematological monitoring is necessary while the patients are on the drug. Further studies involving large number of patients in our country is necessary.






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Online since 20th March '04
Published by Wolters Kluwer - Medknow