Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 7788  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 »   Next article
 »   Previous article
 »   Table of Contents

 Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded0    
    Comments [Add]    
    Cited by others 2    

Recommend this journal


Year : 1995  |  Volume : 43  |  Issue : 4  |  Page : 186--192

Comparative cognitive effects of phenytoin and carbamazepine in adult epileptics.

Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh - 160012, India

Correspondence Address:
Sudhir RV Ravi
Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh - 160012
Login to access the Email id

Source of Support: None, Conflict of Interest: None

PMID: 29542552

Rights and PermissionsRights and Permissions

Forty newly diagnosed, drug naive adult epileptic patients were evaluated for cognitive effects of phenytoin (DPH) and carbamazepine (CBZ). They were randomized into DPH and CBZ groups. Patients with space occupying lesions, progressive degenerative, metabolic and active central nervous system infections were excluded from the study. None of the patients had seizures during the study period. Both the groups were comparable for age, duration as well as type of epilepsy. Full cognitive assessment was carried out using a neuropsychological battery consisting of verbal and performance intelligence, memory, vasomotor function and dysfunction analysis tests before starting the anticonvulsant therapy. The same tests were repeated after 3 months. The mean serum levels of DPH and CBZ at the end of the study period were 19.42 ¤ 4.20 ug/ml and 9.45 ¤ 9.26 ug/ml respectively. The cognitive functions were compared between pre and post study periods in each group and between the two groups. The differences were correlated with serum drug levels. No significant difference in cognitive functioning was noticed in either of the study groups. There was no significant correlation with serum drug levels. It was concluded that both DPH and CBZ have no adverse effects on cognition in adult epileptics with normal therapeutic drug levels.

[PDF Not available]*

Print this article     Email this article

Online since 20th March '04
Published by Wolters Kluwer - Medknow