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| Year : 1993 | Volume
: 41
| Issue : 3 | Page : 147--150 |
A Comparative evaluation of Propofol and thiopentone in prevention of haemodynamic responses to scalp incision during craniotomy.
M Sharma, J Wig, A Agarwal, VK Kak, A Agarawal
Department of Anaesthesiology, Postgraduate Institute of Medical Education and Research, Chandigarh - 160012, India
Correspondence Address:
M Sharma
Department of Anaesthesiology, Postgraduate Institute of Medical Education and Research, Chandigarh - 160012
India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 29542571 
We evaluated the efficacy of Propofol administration in attenuation of the cardiovascular response prior to scalp incision and compared it with the administration of an additional dose of intravenous thiopentone. Thirty patients between 15-50 years of age undergoing elective craniotomy were randomly allocated into 3 groups of 10 each. Group 1 (normal saline) served as control while in group II 2.0 mg/kg of thiopentone was given one minute before scalp incision and in group III propofol 1.0 mg/kg was given one minute before scalp incision. Group I and II patients showed significant tachycardia and hypertension. Rise in heart rate was 26 percent and 9 percent and rise in systolic blood pressure was 21 percent and 13 percent in groups I and II respectively. The changes in cardiovascular parameters in group III were minimal and insignificant except for 12 percent fall in systolic blood pressure one minute after propofol administration. Hence, propofol administration effectively attenuated haemodynamic responses to scalp incision while an additional doses of thiopentone offered only a transient and incomplete protection.
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