Atormac
briv
Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 2820  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
    Next article
    Previous article
    Table of Contents

 Resource Links
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1498    
    Printed59    
    Emailed0    
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal

 

 
Year : 1993  |  Volume : 41  |  Issue : 2  |  Page : 83--85

Accumulation of lipid peroxidation products in human myotonic dystrophic muscle


Neurology Services, Veterans Administration Outpatient Clinic and Department of Neurology, University of Southern California, 351E Temple St, Los Angeles, USA

Correspondence Address:
SK Mishra
Neurology Services, Veterans Administration Outpatient Clinic and Department of Neurology, University of Southern California, 351E Temple St, Los Angeles
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 29542494

Rights and PermissionsRights and Permissions

The possibility of oxygen radical-induced injury contributing to the pathogenesis of muscle disorders was studied. Significant increases in fluorescent lipid peroxidation products was found in the muscle samples of myotonic dystrophy (MyD) patients as compared to controls as well as patients with Duchenne Muscular dystrophy (DMD), Amyotrophic Lateral Sclerosis (ALS), Polymyositis and Limb Girdle Dystrophy (LGD). The results demonstrate the possibility that in MyD the primary genetic disorder leads to the rapid generation of oxygen radicals, tissue depletion of antioxidants followed by peroxidation of membrane lipids, impaired calcium homeostasis and finally atrophy of the muscle.






[PDF Not available]*


        
Print this article     Email this article

Online since 20th March '04
Published by Wolters Kluwer - Medknow