|Year : 1993 | Volume
| Issue : 2 | Page : 69--72
Role of urokinase in the management of experimental intraventricular hemorrhage in canine model - Part 2 : effects of direct instillation of urokinase on dissolution of an intraventricular clot.
AK Chand, D Rout
Department of Neurosurgery, Sree Chitra Tirunal Institute of Medical Sciences and Technology, Trivandrum, India
An experimental intraventricular haemorrhage (IVH) model was developed in nine adult dogs. Urokinase, a thrombolytic agent, was injected into the ventricle of five animals through a catheter-reservoir system described in the earlier part. Four canine models served as a control. The dosage determination and the methodology of instillation of urokinase were described. Following this the animals were observed for any bleeding disorder and the neurologic status. Dissolution of the clot was demonstratedin the urokinase treated dogs by serial clinical examination, Ventriculography and post mortem studies. Absence of side effects with this mode of administration was emphasised.
Department of Neurosurgery, Sree Chitra Tirunal Institute of Medical Sciences and Technology, Trivandrum
Source of Support: None, Conflict of Interest: None
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